Phospho-Src Family (Tyr416) An

src基因

src 的产物 p60src 具有 TPK （酪氨酸蛋白激酶）活性，分子量约为 60KDa ，与细胞的增殖和转化有关。 Src 蛋白有四个结构域： （1） N 端十四烷基化位点是和膜结合的位点； （2） SH2 （ src homology region-2 ）结构域能和自身的或其它蛋白的磷酸化酪氨酸位点结合，传递信号。 （3） 416 位 Tyr 的自身磷酸化和细胞的转化活性有关。

Analysis of Myristoylated and Palmitoylated Src Family Proteins

Several hundred viral and cellular proteins have been shown to be covalently modified by fatty acids (1 –3 ). The two most common modifications, myristoylatron and palmitoylatron, differ with respect to the type and chemical nature of fatty

Using Phospho‐Motif Antibodies to Determine Kinase Substrates

comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available