Recombinant Salamander Leptin

AAV-Mediated Gene Transfer to Skeletal Muscle

to nondividing cells such as muscle fibers or hepatocytes following in vivo transduction (1 –7 ). Recombinant AAV can be administered to skeletal muscle of experimental animals and, as recently documented in a Phase I clinical trial, to humans at high vector

Overview of Animal Models of Obesity

of obesity most commonly utilized in research. The models include monogenic models in the leptin pathway, polygenic diet?dependent models, and, in particular for their historical perspective, surgical and chemical models of obesity. However, there are far

Adeno‐Associated Viral Vectors for Anterograde Axonal Tracing with Fluorescent Proteins in Nontransgenic and Cre Driver Mice

the natural ability of viruses to infect post?mitotic cells such as neurons has provided an explosion of new methods to manipulate and reconstruct neural circuits in vivo. Here we describe the use of recombinant adeno?associated viral vectors (rAAV) for axonal