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冷藏/冷冻
-20
Globular Adiponectin Human Recombinant
大量
上海经科化学科技有限公司
无
5μg/25μg/1mg
Synonyms | Acrp30, AdipoQ, GBP-28, APM-1, ACDC. |
Introduction | Adiponectin is a protein exclusively secreted from adipose tissue. In the circulation, adiponectin is present as three different oligomeric complexes, including the high molecular weight (HMW), the middle molecular weight (MMW, also called hexamer) and low molecular weigh (LMW, also called trimer) forms. Different oligomeric complex of adiponectin activates different signaling pathways and exerts distinct functions. |
Description | Acrp30 Human has a total of 171 amino acids. N-terminal underlined amino acids are His-tag and the protease cleavage site (31AA-Underlined). The AA sequence of Acrp30 Human is homologous to the 105-244 amino acid sequence of the Human full-length Adiponectin. |
Source | Escherichia Coli. |
Purity | Purity of Acrp30 Human is greater than 95% as determined by HPLC and SDS PAGE. |
Amino Acid Sequence | MSWWHHHHHH NWNIPTTQDT TQDLWFEGAM GGEGAYVYRS FSVGLETYV TIPNMPIRFT KIFYNQQNHYDGSTGKFHCN IPGLYYFAYH ITVYMKDVKV SLFKKDKAML FTYDQYQENN VDQASGSVLL HEVGDQVWLQVYGEGERNGL YADNDNDSTF TGFLLYHDTN (Swiss-prot entry Q15848). |
Formulation | Acrp30 Human is a filtered powder, lyophilized from 0.6 mg/ml in PBS buffer. |
Solubility | Add 0.2 ml of deionized water and let the lyophilized pellet of Acrp30 Human dissolve completely. |
Stability | For long term, store lyophilized Acrp30 Human at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted Acrp30 Human can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized Acrp30 Human remains stable for 24 months when stored at -20°C. |
Catalogue Number | CYT-615 |
Synonyms | Acrp30, AdipoQ, GBP-28, APM-1, ACDC. |
Introduction | gAcrp30 globular protein, exists as a result of proteolytic processing of adiponectin. Adiponectin is manufactured and secreted solely by adipocytes, and is a highly obtained plasma protein, accounting for up to 0.05% of total serum protein. Similar to Adiponectin, gAcrp30 is able of lowering hyperglycemia and reversing insulin resistance. In addition, gAcrp30 is an significant protein that is involved in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids. AdipoR1 & AdipoR2 are the 2 signaling receptors for adiponectin and gAcrp30 that were recently been identified. |
Description | gAcrp30 Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated, Polypeptide chain containing 145 amino acids and having a molecular mass of 16.7kDa. The gAcrp30 is purified by proprietary chromatographic techniques. |
Source | Escherichia Coli. |
Formulation | Sterile filtered and lyophilized from 1mg/ml in 10mM Tris pH-8 & 0.75mM DTT. |
Solubility | We recommended reconstituting gAcrp30 at a concentration of 0.1-1mg per ml with 5mM Tris pH-8 and 0.75mM DTT which can then be further diluted to other aqueous solutions. |
Stability | For long term, store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time two weeks. |
Purity | Greater than 95% as determined by SDS-PAGE. |
Amino Acid Sequence | MKGEPGEGAY VYRSAFSVGL ETYVTIPNMP IRFTKIFYNQ QNHYDGSTGK FHCNIPGLYY FAYHITVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTN. |
Biological Activity | gAcrp30 activity is determined by its ability to inhibit the proliferation of mouse M1 cells. The expected ED50 for this effect is 0.36-0.54 µg/ml. |
Usage | Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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