T细胞无反应性和免疫耐受PCR芯片T-cell Anergy

T细胞无反应性和免疫耐受PCR芯片可用于研究T细胞无反应性和免疫耐受相关的84个关键基因的表达。T细胞的功能无反应性是产生外周自身免疫耐受的细胞固有机制。该芯片包含了T细胞和B细胞调节因子、细胞因子、受体以及TNF超级家族成员、它们的对应受体和转录因子。通过实时定量PCR，研究者可以简单可靠地同时分析T细胞无反应性和免疫耐受相关基因的表达。
T-Cell Regulators: BTLA, CBLB, CD27, CD28, FAS, FOXP3, IL15, IL2, IL2RA, IL4, LAT, TGFB1, TNFRSF14, TNFSF14. B-Cell Regulators: BTLA, CD27, CD40, CD40LG, FOXP1, FOXP3, HDAC9, IL4. Cytokines, Receptors and their related Proteins: CCL3L1, CCR4, CD40LG, CD70, CSF1, CSF2, FASLG, IFNG, IL10, IL10RA, IL13, IL15, IL17A, IL1A, IL2, IL2RA, IL2RB, IL31, IL4, IL5, IL6, IL7R, LEP, LTA, PRF1, PTGER2, PTGS2, TGFB1, TNFSF10, TNFSF14, TNFSF8. TNF Superfamily Members and their Receptors: CD40LG, CD70, FAS, FASLG, LTA, TNFRSF10A, TNFRSF4, TNFRSF18, TNFRSF4, TNFRSF8, TNFRSF9, TNFSF10, TNFSF14, TNFSF8. Transcriptional Regulators: CDK2, CDK4, EGR2, EGR3, EOMES, FOS, FOXP1, FOXP2, FOXP3, GATA3, HDAC9, IFNG, ING4, IRF4, JAK3, JUN, MEF2A, NFATC1, NFATC2, NFATC3, NFKB1, NHLH2, NOTCH1, STAT3, STAT6, TBX21, TGFB1. Other Genes involved in T-cell Anergy: CMA1, CTLA4, DGKA, DGKZ, GZMB, ICAM1, ICOS, ITCH, ITGA1, JAK1, LGALS3, PDCD1, PRKCG, RNF128, SELL.