帕金森病PCR基因芯片Parkinson's Disease

帕金森病PCR基因芯片可用于研究直接或可能参与帕金森病（PD）的84个关键基因的表达。帕金森病是一种由多巴胺能神经元的损失导致的神经退行性疾病。虽然有关于PD的遗传基因方面的研究，但大多数结果是零散的。基于PD动物模型的表达谱芯片筛查有助于研究PD的发生和发展的机制。例如，研究表明PARK家族的基因不但在继承性PD失常，在偶发性PD中也同样表达失调。此外，该研究还发现参与离子转运的基因，如ATP2B2在PD中同样表达失调。因此，PD研究不但集中在已知的突变基因，如α-突触核蛋白（SNCA）和Parkin （PARK2），还包括在那些通过芯片实验发现的新基因。该PCR芯片包括已知的PD相关的基因和它们的调控基因，以及那些通过在PD模型动物上芯片筛选出的差异基因。这些基因在PD中介导多种细胞功能失调，如泛素化、离子运输、细胞凋亡和多巴胺信号。使用实时定量PCR，研究者可以方便并且可信地研究帕金森病相关基因的表达

Product	Species	Technology	Cat. No.
Parkinson's Disease PCR Array	Human	Gene Expression	PAHS-124Z
Parkinson's Disease PCR Array	Mouse	Gene Expression	PAMM-124Z
Parkinson's Disease PCR Array	Rat	Gene Expression	PARN-124Z

Parkin Complex: HSPA4 (HSP70), PARK7, STUB1.
Parkin Substrate: ATXN2, ATXN3, GPR37, SYT11.
Cell Adhesion: APC, APP, CDH8, FN1, NFASC, NRXN3, PTEN, TPBG.
Ubiquitination: CDC27, CUL2, FBXO9, LRRK2, PAN2, PARK2, PINK1, SKP1, STUB1, UBB, UBA1, UBE2I, UBE2K, UBE2L3, UCHL1, USP34.
Inflammation: FN1, PRDX2, YWHAZ.
Apoptosis:
Pro-Apoptosis: APC, APP, CASP1 (ICE), CASP3, CASP8 (FLICE), CASP9, CUL2, MAPK9 (JNK2), PSEN2, PTEN.
Anti-Apoptosis: APC, BDNF, CASP3, CASP9, NEFL, NR4A2 (NUR77), OPA1, PPID, PRDX2, PSEN2, PTEN, SLC25A4, SNCA, TCF7L2, UBB, YWHAZ.
Mitochondria: CASP3, CASP7, CASP8 (FLICE), HSPA4 (HSP70), LRRK2, NEFL, OPA1, PARK7, PINK1, PTEN, SLC25A4, SNCA, TH, UCHL1, VAMP1, VDAC3, YWHAZ.
Synaptic Vesicles: LRRK2, SEPT5, SV2B, SYNGR3, SYT1, SYT11, TH.
Signal Transduction:
Dopaminergic: D4S234E, DDC, DRD2, HTR2A, NR4A2 (NUR77), PARK2, PARK7, PINK1, SEPT5, SLC6A3, SNCA, TH.
GABAergic: DRD2, GABBR2.
MAP Kinase: APC, FGF13, MAPK9 (JNK2), PRDX2, RGS4.
Notch: APP, PSEN2, SPEN.
Cytoskeletal Organization: APC, CDC42, MAPT, NEFL, PARK2.
Ion Transport: ATP2B2, CADPS, CXXC1, DRD2, EGLN1, GBE1, GRIA3, HTR2A, KCNJ6, NSF, PSEN2, S100B, SRSF7, SLIT1, SNCA, VDAC3.
Transporters: ATP2B2, GRIA3, SLC18A2, SLC6A3, SLC25A4, SV2B, SYT1, SYT11, VDAC3.
Others: ALDH1A1, BASP1, CHGB, DLK1, NCOA1, NTRK2, RTN1.