帕金森病PCR基因芯片 Parkinson's Diseas

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Parkinson's Disease PCR Arrays

帕金森病PCR基因芯片

Product	Species	Technology	Cat. No.
Parkinson's Disease PCR Array	Human	Gene Expression	PAHS-124Z
Parkinson's Disease PCR Array	Mouse	Gene Expression	PAMM-124Z
Parkinson's Disease PCR Array	Rat	Gene Expression	PARN-124Z

Parkinson's Disease RT² Profiler™ PCR Array profiles the expression of 84 key genes directly or potentially involved in Parkinson's disease (PD). PD is a neurodegenerative disorder caused by loss of dopaminergic neurons. Although there are inheritable genetic forms of PD, the majority of diagnoses are sporadic PD, where the cause is unknown. Gene expression microarray analyses of multiple PD animal models have shed insight into the mechanism of PD initiation and progression. For example, one microarray study shows that genes of the PARK family, central to inheritable PD, are also dysregulated in patients diagnosed with sporadic PD. In addition, this study identifies dysregulated genes involved in ion transport, such as ATP2B2. Therefore, PD research focuses on both known mutated genes, such as Alpha-synuclein (SNCA) and Parkin (PARK2), as well as novel genes identified from microarray experiments. This array includes known PD genes and their interactors, as well as genes whose expression changes across multiple human, mouse, rat and macaque PD microarray analyses. These genes mediate multiple cellular functions dysregulated in PD, such as ubiquitination, ion transport, apoptosis and dopaminergic signaling. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of genes involved in Parkinson's disease progression with this array.
帕金森病PCR基因芯片可用于研究直接或可能参与帕金森病（PD）的84个关键基因的表达。帕金森病是一种由多巴胺能神经元的损失导致的神经退行性疾病。虽然有关于PD的遗传基因方面的研究，但大多数结果是零散的。基于PD动物模型的表达谱芯片筛查有助于研究PD的发生和发展的机制。例如，研究表明PARK家族的基因不但在继承性PD失常，在偶发性PD中也同样表达失调。此外，该研究还发现参与离子转运的基因，如ATP2B2在PD中同样表达失调。因此，PD研究不但集中在已知的突变基因，如α-突触核蛋白（SNCA）和Parkin （PARK2），还包括在那些通过芯片实验发现的新基因。该PCR芯片包括已知的PD相关的基因和它们的调控基因，以及那些通过在PD模型动物上芯片筛选出的差异基因。这些基因在PD中介导多种细胞功能失调，如泛素化、离子运输、细胞凋亡和多巴胺信号。使用实时定量PCR，研究者可以方便并且可信地研究帕金森病相关基因的表达。
Parkin Complex:HSPA4 (HSP70), PARK7, STUB1.
Parkin Substrate:ATXN2, ATXN3, GPR37, SYT11.
Cell Adhesion:APC, APP, CDH8, FN1, NFASC, NRXN3, PTEN, TPBG.
Ubiquitination:CDC27, CUL2, FBXO9, LRRK2, PAN2, PARK2, PINK1, SKP1, STUB1, UBB, UBA1, UBE2I, UBE2K, UBE2L3, UCHL1, USP34.
Inflammation:FN1, PRDX2, YWHAZ.
Apoptosis:
Pro-Apoptosis:APC, APP, CASP1 (ICE), CASP3, CASP8 (FLICE), CASP9, CUL2, MAPK9 (JNK2), PSEN2, PTEN.
Anti-Apoptosis:APC, BDNF, CASP3, CASP9, NEFL, NR4A2 (NURR1), OPA1, PPID, PRDX2, PSEN2, PTEN, SLC25A4, SNCA, TCF7L2, UBB, YWHAZ.
Mitochondria:CASP3, CASP7, CASP8 (FLICE), HSPA4 (HSP70), LRRK2, NEFL, OPA1, PARK7, PINK1, PTEN, SLC25A4, SNCA, TH, UCHL1, VAMP1, VDAC3, YWHAZ.
Synaptic Vesicles:LRRK2, SEPT5, SV2B, SYNGR3, SYT1, SYT11, TH.
Signal Transduction:
Dopaminergic:NSG1, DDC, DRD2, HTR2A, NR4A2 (NURR1), PARK2, PARK7, PINK1, SEPT5, SLC6A3, SNCA, TH.
GABAergic:DRD2, GABBR2.
MAP Kinase:APC, FGF13, MAPK9 (JNK2), PRDX2, RGS4.
Notch:APP, PSEN2, SPEN.
Cytoskeletal Organization:APC, CDC42, MAPT, NEFL, PARK2.
Ion Transport:ATP2B2, CADPS, CXXC1, DRD2, EGLN1, GBE1, GRIA3, HTR2A, KCNJ6, NSF, PSEN2, S100B, SRSF7, SLIT1, SNCA, VDAC3.
Transporters:ATP2B2, GRIA3, SLC18A2, SLC6A3, SLC25A4, SV2B, SYT1, SYT11, VDAC3.
Others:ALDH1A1, BASP1, CHGB, DLK1, NCOA1, NTRK2, RTN1.