自噬PCR芯片Autophagy PCR Array

自噬PCR芯片可用于研究参与自噬反应的84个关键基因的表达。自噬是一种细胞内的代谢过程，是通过溶酶体吞噬细胞中的受损蛋白和细胞器的过程。自噬作用已经被证明与很多正常的生理过程有关，如能量代谢、细胞器翻转、生长调节和老化。自噬受损将会导致心肌疾病和癌症等。该一芯片包含了与细胞内外信号通路有关的自噬的分子基因，及其关键调控因子基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测自噬相关基因的表达。

Product	Species	Technology	Cat. No.
Autophagy PCR Array	Human	Gene Expression	PAHS-084Z
Autophagy PCR Array	Mouse	Gene Expression	PAMM-084Z
Autophagy PCR Array	Rat	Gene Expression	PARN-084Z
Autophagy PCR Array	Rhesus Macaque	Gene Expression	PAQQ-084Z
Autophagy PCR Array	Pig	Gene Expression	PASS-084Z

Autophagy Machinery Components: Genes Involved in Autophagic Vacuole Formation: AMBRA1 (NYW1), ATG12, ATG16L1, ATG4A, ATG4B, ATG4C, ATG4D, ATG5, ATG9A, ATG9B, BECN1, GABARAP, GABARAPL1, GABARAPL2, IRGM, MAP1LC3A, MAP1LC3B, RGS19, ULK1, WIPI1. Genes Responsible for Protein Targeting to Membrane / Vacuole: ATG4A, ATG4B, ATG4C, ATG4D, GABARAP. Genes Responsible for Protein Transport: ATG10, ATG16L1, ATG16L2, ATG3, ATG4A, ATG4B, ATG4C, ATG4D, ATG7, ATG9A, GABARAP, GABARAPL2, RAB24. Genes Linking Autophagosome to Lysosome: DRAM1, GABARAP, LAMP1, NPC1. Genes Involved in Protein Ubiquitination: ATG3, ATG7, HDAC6. Genes with Protease Activity: ATG4A, ATG4B, ATG4C, ATG4D. Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis: AKT1, APP, ATG12, ATG5, BAD, BAK1, BAX, BCL2, BCL2L1 (BCL-X), BECN1, BID, BNIP3, CASP3, CASP8 (FLICE), CDKN1B (p27KIP1), CDKN2A (p16INK4), CLN3, CTSB, CXCR4, DAPK1, DRAM1, EIF2AK3, FADD, FAS (TNFRSF6), HDAC1, HTT, IFNG, IGF1, INS, MAPK8 (JNK1), MTOR, NFKB1, PIK3CG, PRKAA1, PTEN, SNCA, SQSTM1, TGFB1, TGM2,TNF, TNFSF10 (TRAIL), TP53. Co-Regulators of Autophagy and the Cell Cycle: BAX, CDKN1B (p27KIP1), CDKN2A (p16INK4), IFNG, PTEN, RB1, TGFB1, TP53. Autophagy Induction by Intracellular Pathogens: EIF2AK3, IFNG, LAMP1. Autophagy in Response to Other Intracellular Signals: CTSD, CTSS, DRAM2 (TMEM77), EIF4G1, ESR1 (ERa), GAA, HGS, MAPK14, PIK3C3 (VPS34), PIK3R4, RPS6KB1, TMEM74, ULK2, UVRAG. Chaperone-Mediated Autophagy: HSP90AA1, HSPA8.