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- Oncogenes & Tumor Suppressor Genes ChIP PCR Array
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- 2025年12月31日
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- 服务名称：
Oncogenes & Tumor Suppressor Genes ChIP PCR Array
- 提供商：
SAB
| Oncogenes & Tumor Suppressor Genes PCR Array 原癌基因和抑癌基因PCR芯片 |
| Product | Species | Technology | Cat. No. |
| Oncogenes & Tumor Suppressor Genes PCR Array | Human | Gene Expression | PAHS-502Z |
| Oncogenes & Tumor Suppressor Genes PCR Array | Mouse | Gene Expression | PAMM-502Z |
| Oncogenes & Tumor Suppressor Genes PCR Array | Rat | Gene Expression | PARN-502Z |
原癌基因和抑癌基因PCR芯片可用于研究促进癌变的84个核心基因的表达。此芯片所含的基因，有致癌或抑癌或两者兼有，取决于肿瘤的类型也来源于已知的或相匹配的正常组织的基因表达差异。利用肿瘤样本来分析这些基因的表达，可能与它们的生物学表型或临床结果如临床分期、治疗方案的选择、转移、复发和生存率等等有关。结果也可以深入了解肿瘤发生和肿瘤病理学发生的分子机制和生物学途径，包括解除管制的细胞凋亡、细胞周期、细胞黏附、DNA损伤和修复以及信号转导。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测肿瘤发生相关基因的表达。
Oncogenes: BAX, BCL2L1, CA SP8, CDK4, ELK1, ETS1, HGF, JAK2, JUNB, JUND, KIT, KITLG, MCL1, MET, MOS, MYB, NFKBIA, NRAS, PIK3CA, PML, PRKCA, RAF1, RARA, REL, ROS1, RUNX1, SRC, STAT3, ZHX2.
Tumor Suppressor Genes: ATM, BRCA1, BRCA2, CDH1, CDKN2B, CDKN3, E2F1, FHIT, FOXD3, HIC1, IGF2R, MEN1, MGMT, MLH1, NF1, NF2, RASSF1, RUNX3, S100A4, SERPINB5, SMAD4, STK11, TP73, TSC1, VHL, WT1, WWOX, XRCC1.
Both Oncogenic & Tumor Suppressor Properties: BCR, EGF, ERBB2, ESR1, FOS, HRAS, JUN, KRAS, MDM2, MYC, MYCN, NFKB1, PIK3C2A, RB1, RET, SH3PXD2A, TGFB1, TNF, TP53.
Transcription Factors: ABL1, BRCA1, BRCA2, CDKN2A, CTNNB1, E2F1, ELK1, ESR1, ETS1, FOS, FOXD3, HIC1, JUN, JUNB, JUND, MDM2, MEN1, MYB, MYC, MYCN, NF1, NFKB1, PML, RARA, RB1, REL, RUNX1, RUNX3, SMAD4, STAT3, TGFB1, TNF, TP53, TP73, TSC1, VHL, WT1, ZHX2.
Epithelial-to-Mesenchymal Transition: BRCA2, CDKN2B, CTNNB1, ERBB2, HGF, JAK2, KIT, MCL1, NF1, RUNX3, S100A4, SMAD4, TGFB1, VHL.
Angiogenesis: AKT1, CTNNB1, EGF, ERBB2, NF1, PML, RUNX1, TGFB1.
Apoptosis: BAX, BCL2, BCL2L1, BRCA1, CASP8, E2F1, MCL1, MGMT, TNF, VHL.
Cell Adhesion: APC, CDH1, CDKN2A, CTNNB1, KITLG, NF1, NF2, TGFB1.
Cell Cycle: ATM, BRCA1, BRCA2, CCND1, CDK4, CDKN1A, CDKN2A, CDKN2B, CDKN3, E2F1, HGF, MEN1, STK11, TP53
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文献和实验Representational Difference Analysis as a Tool in the Search for New Tumor Suppressor Genes
The recognition of a homozygous deletion of genetic material in a tumor genome has been instrumental in several tumor suppressor gene searches. The representational difference analysis (RDA) allows one to identify homozygous deletions
mutations in BRCA1, BRCA2, mismatch repair genes, or p53 (detailed in Subheading 2.2 .). Somatic mutations have been found in sporadic ovarian cancers that activate oncogenes or that result in loss of tumor suppressor gene function. Different ovarian cancers
Chromatin Immunoprecipitation (ChIP)
cross-linking agent for ChIP and the use of polymerase chain reaction (PCR) to detect precipitated DNA fragments were later added as components of the modern ChIP procedure. The protocol below represents a standard ChIP procedure for use in mammalian
