骨骼肌：成肌及肌病PCR基因芯片Skeletal Muscl

骨骼肌：成肌及肌病PCR基因芯片可以同时检测与骨骼肌分化、功能与疾病相关的84个关键基因的表达。骨骼肌的随意运动，极大地促进能量代谢和胰岛素调节葡萄糖的摄取和存储。老化及代谢性疾病，如糖尿病和代谢综合征的并发症会导致肌肉萎缩。然而，最近的研究推测骨骼肌的代谢缺陷有助于糖尿病和代谢综合征的发病，表明在这些疾病状态中骨骼肌比最初预期有更大的作用。巨型的多源蛋白复合体，例如titin或dystrophin，会促进骨骼肌细胞的细胞骨架连接到细胞外基质上，并引起肌肉收缩。这些复合物组成蛋白的遗传性突变和相关基因表达的变化都会引起肌营养不良症。治疗肌肉萎缩的可行性方案包括促进生成新的肌肉细胞（成肌）或提升肌肉细胞的质量。该芯片包括参与骨骼肌基本功能，发展和增长的重要基因，及与代谢综合征和肌肉萎缩的疾病相关的基因。利用实时定量PCR，研究者可以方便并且可信地对骨骼肌肉的发育和疾病有关基因进行同时检测。

Product	Species	Technology	Cat. No.
Skeletal Muscle: Myogenesis & Myopathy PCR Array	Human	Gene Expression	PAHS-099Z
Skeletal Muscle: Myogenesis & Myopathy PCR Array	Mouse	Gene Expression	PAMM-099Z
Skeletal Muscle: Myogenesis & Myopathy PCR Array	Rat	Gene Expression	PARN-099Z
Skeletal Muscle: Myogenesis & Myopathy PCR Array	Rhesus Macaque	Gene Expression	PAQQ-099Z

Skeletal Muscle Contractility:
Dystrophin-Glycoprotein Complex: CAMK2G, CAPN3, CAV3, DAG1, DMD (Dystrophin), DYSF, LMNA, MAPK1, SGCA.
Titin Complex: ACTA1, ACTN3, CAPN3, CRYAB, DES, LMNA, MAPK1, MSTN, MYH1, MYH2, MYOT, NEB, SGCA, TNNI2, TNNT1, TNNT3, TRIM63 (MuRF1), TTN.
Energy Metabolism: CS, HK2, PDK4, SLC2A4 (GLUT4).
Fast-Twitch Fibers: ATP2A1, MYH1, MYH2, TNNI2, TNNT3.
Slow-Twitch Fibers: MB, MYH1, TNNC1, TNNT1. Other: DMPK, IKBKB, RPS6KB1.
Skeletal Myogenesis: ACTA1, ADRB2, AGRN, BCL2, BMP4, CAPN2, CAST, CAV1, CTNNB1, DMD, HDAC5, IGF1, IGFBP3, IGFBP5, MEF2C, MSTN, MUSK, MYF5, MYF6, MYOD1, MYOG, PAX3, PAX7, PPP3CA (Calcineurin Aa), RHOA, RPS6KB1, UTRN.
Skeletal Muscle Hypertrophy: ACTA1, ACVR2B, ADRB2, IGF1, IGFBP5, MSTN, MYF6, MYOD1, RPS6KB1.
Skeletal Muscle Autocrine Signaling: ADIPOQ, FGF2, IGF1, IGF2, IL6, LEP, MSTN, TGFB1.
Diabetes/Metabolic Syndrome: ADIPOQ, LEP, PPARG, PPARGC1A (PGC-1a), PPARGC1B (PGC-1ß), PRKAA1 (AMPK), PRKAB2, PRKAG1, PRKAG3, SLC2A4 (GLUT4).
Skeletal Muscle Wasting/Atrophy: Autophagy: CAPN2, CASP3, FBXO32 (Atrogin-1), FOXO1, FOXO3, MSTN, NOS2, PPARGC1A (PGC-1a), PPARGC1B (PGC-1ß), RPS6KB1, TRIM63 (MuRF1).
Dystrophy: AKT1, AKT2, FBXO32 (Atrogin-1), IL1B, MAPK1, MAPK14, MAPK3, MAPK8, MMP9, NFKB1, TNF, TRIM63 (MuRF1), UTRN.