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文献和实验Antibody–drug conjugates (ADCs) combine the selectivity of a monoclonal antibody with the killing potency of a cytotoxic drug. For an antibody to function as a successful component of an ADC, it needs to bind to the target antigen
Preparation of Polysaccharide-Conjugate Vaccines
the immunogenicity of (poly)saccharides ( 2 , 3 ). We now know that the carrier proteins ensure the involvement of T-helper lymphocytes in the activation of the hapten- or polysaccharide-specific antibody-producing B lymphocytes (Fig. 1 ). In contrast
AntibodyDrug Conjugate (ADC) Clinical Pipeline: A Review
of improved compounds which are now in clinical trials. Brentuximab vedotin (Adcetris� ), an anti-CD30 antibody conjugated to a potent microtubule inhibitor for the treatment of Hodgkin’s lymphoma and anaplastic large cell lymphomas, is the only marketed ADC
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