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- Chimerigen
- 美国
- CHI-HF-211PDL1
- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保质期：
1年
- 英文名：
PDL1
- 库存：
大量
- 供应商：
江苏弗泰生物科技有限公司
- 保存条件：
低温保存
Cat# CHI-HF-211PDL1
CD274 [B7-H1/PD-L1] (human):Fc (mouse) (rec.)
CHI-HF-211PDL1-C100 100 µg ￥2,560
GENERAL INFORMATION
| Synonyms : | PDL1; Programmed Cell Death 1 Ligand Protein 1; PDCD1 Ligand 1; B7-H1 |
| Host : | CHO cell |
| Sequence : | The extracellular domain of human PDL1 (NP_054862.1) ( Phe19-Arg238) is fused to the N-terminus of the Fc region of mouse IgG2a. |
| Molecular Mass: | 54 KDa (monomer) |
SPECIFICATIONS
| Purity : | >98%，by SDS-PAGE under reducing conditions. |
| Endotoxin Content : | <0.06 EU/μg as determined by LAL test. |
| Activity: | Measured by its ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T lymphocytes. |
| Formulation : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Use / Stability : |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Avoid freeze/thaw cycles. | |
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文献和实验，PD-1/PD-L1这么值钱，大家一定好奇它到底是什么鬼。 PD-1全名是程序性死亡分子1(programmed death-1)是Ishida等[1]通过消减杂交技术于1992年发现的[2]，是CD28家族成员，胞质区含有2个酪氨酸残基，1个位于靠近N端的免疫受体酪氨酸抑制基序(ITIM)中，另一个1个位于靠近C端的免疫受体酪氨酸转化基序(ITSM)中[2]。 PD-L1(CD274)是B7家族成员，是PD-1的配体，属于1型跨膜蛋白，全长290个氨基酸，包含1个IgV样
containing the human Lhcgr gene into a 170 kb BAC clone comprising the entire mouse orthologue. The methodology is based on the rationale to introduce a counter-selection cassette flanked by unique restriction sites and HAs for the insert, into the vector
was unresponsive to the transcription factors (Fig. 4D). The sequence 5'-GGAA-3' (ETS-binding site-2, EBS2) is conserved between mouse and the human promoters, and in the mouse it interacts with the ETS-1 protein, a transcription factor of the ETS family expressed
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