Necrosulfonamide

1) Cat. No.: TRC-N388600; 2) Chemical Name: Necrosulfonamide; 3) CAS No.: 432531-71-0; 4) Mol. Formula: C18H15N5O6S2; 5) Mol. Weight: 461.47; 6) Packing Size: 1mg / 10mg; 7) Appearence: Yellow Solid; 8) Application Notes: Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.; 9) Synonym: N-[4-[[(3-Methoxypyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide;; 10) Solubility: DMSO, Methanol; 11) Storage condition: Amber Vial, Refrigerator, Under Inert Atmosphere; 12) References: Sun, L. et al.: Cell, 148, 213 (2012);