Necrosulfonamide-d4

1) Cat. No.: TRC-N388602; 2) Chemical Name: Necrosulfonamide-d4; 3) CAS No.: ; 4) Mol. Formula: C18H11D4N5O6S2; 5) Mol. Weight: 465.5; 6) Packing Size: 1mg / 10mg; 7) Appearence: Pale Yellow Solid; 8) Application Notes: Labelled Necrosulfonamide. Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.; 9) Synonym: N-[4-[[(3-Methoxypyrazinyl)amino]sulfonyl](phenyl]-d4)-3-(5-nitro-2-thienyl)-2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl](phenyl-d4)]-3-(5-nitrothiophene-2-yl)acrylamide;; 10) Solubility: DMSO, Methanol; 11) Storage condition: Amber Vial, Refrigerator, Under Inert Atmosphere; 12) References: Sun, L. et al.: Cell, 148, 213 (2012);