LLO, rec.

Mannose-6-Phosphate: A Regulator of LLO Destruction

Oligosaccharyltransferase (OT) catalyzes the signature reaction of the asparagine-linked glycosylation pathway, namely, the transfer of preformed glycans from the lipid-linked oligosaccharide Glc3Man9GlcNAc2-P-P-Dolichol (G3 M9 Gn2 -LLO

Determination of Cell-Specific Receptor Binding Using a Combination of Immunohistochemistry and In Vitro Autoradiography: Relevance to Therapeutic Rec

Mapping of receptor binding to specific structures, or cells within tissue samples, provides valuable information regarding biological and pathological mechanisms. Such information may potentially be translated into targeted therapies

张锋团队再获新进展！Nature 发文解析「超迷你」核酸酶 IsrB 结构及 DNA 切割机制

的开发和改造提供了理论基础。 图片来源：Nature 像 IscB 和 Cas9 一样，IsrB 含有一个 RuvC 样核酸酶结构域，该结构域被桥螺旋结构截断。IsrB 长度仅有约 350 个氨基酸，相比 IscB（Cas9 的祖先）缺少 HNH 核酸酶结构域，同时也缺失 Cas9 的 REC lobe（参与靶标识别）和 PAM 序列互作域。作者推测 IsrB 通过 ωRNA 形成的复杂的三元结构来弥补 REC 的作用。 IsrB 还含有一个 N 端 PLMP 结构域（以其保守的氨基酸基序