- 询价
- GenScript/金斯瑞
- 中国
- Z03570-50
- 2026年08月19日
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- 库存：
42
- 供应商：
广州市左克生物
- 规格：
50 μg
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产品简介:
货号：Z03570-50
产品名称：Siglec-10 Fc Chimera, Human
产品规格：50 μg
产品介绍文本：Siglec-10 is immune system-restricted and highly expressed in peripheral blood leukocytes. Siglec-10 preferably binds to α-2,3- or α-2,6-linked sialic acid (similarity). Siglec10 is involved in the negative regulation of B cell antigen receptor signal transduction. The inhibition of B cell acti...
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| Species | Human | ||||
| Protein Construction |
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| Purity | > 90% as analyzed by SDS-PAGE | ||||
| Endotoxin Level | < 1 EU/μg of protein by gel clotting method | ||||
| Biological Activity | Immobilized CD24-His (CD4-H52H3-100 µg) at 5.0 μg/ml (100 μl/well) can bind Siglec-10, hFc, Human. | ||||
| Expression System | HEK 293 | ||||
| Apparent Molecular Weight | ~85.9 kDa, on SDS-PAGE under reducing conditions. | ||||
| Formulation | Supplied as a solution in PBS, pH 7.0-7.2. | ||||
| Concentration | Please refer to the COA for the specific lot. | ||||
| Storage & Stability | Upon receiving, this product remains stable for 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles. |
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技术背景HTML：
| Target Background | Siglec-10 is immune system-restricted and highly expressed in peripheral blood leukocytes. Siglec-10 preferably binds to α-2,3- or α-2,6-linked sialic acid (similarity). Siglec10 is involved in the negative regulation of B cell antigen receptor signal transduction. The inhibition of B cell activation depends on PTPN6/SHP-1 (by similarity). The binding of Siglec10 to CD24 may be involved in the selective suppression of the immune response (by similarity) to risk-related molecular patterns (DAMPs) (such as HMGB1, HSP70 and HSP90). The combination of Siglec10 and CD24 may regulate the immune response of natural killer (NK) cells. Play a role in controlling autoimmunity (by similarity). In the process of initiating an adaptive immune response by CD8-α+ dendritic cells, cross-presentation is inhibited by weakening the formation of MHC class I peptide complexes. The function seems to imply the recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex, thereby promoting phagosome acidification (by similarity). |
| Synonyms | Sialic acid binding Ig-like lectin 10; MGC126774; PRO940; SIGLEC-10; SLG2 |
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文献和实验Quantification of Human IgG and Related Fc Fusion Proteins by a Human IgG/Fc Capture ELISA
of recombinant human IgGs after production and purification for further assays. Here, we describe a human IgG/Fc capture enzyme linked immunosorbent assay (ELISA) which is simple, robust, inexpensive and specific for all types of human IgGs and related Fc fusion
cells. We present here (i) a detailed protocol for the production and purification of soluble recombinant NK cell receptors tagged with human IgG1-Fc (thus termed receptor-Fc chimera or receptor-Ig fusion protein) and (ii) a protocol for cell staining
为对兔疫球蛋白Fc部分c末端的受体。对具有该受体的细胞，通过抗体与抗原结合时，细胞将发挥如下的特有机能：（1）原噬菌体对IgG，占多形核白细胞大部分的嗜中性细胞对IgG、IgA具有Fc受体，通常通过与抗原结合的抗体以及有时与游离的抗体（嗜细胞性抗体）结合来捕捉抗原，并经吞噬作用将之围吞。（2）B细胞的大部分（80%以上）具有对IgG的Fc受体，这些都不进行产生抗体的细胞分化，可通过与抗原抗体复合体的结合而被活化，释放产生抗体的细胞限制因子。（3）T细胞约有10%具有Fc受体，主要
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