- ￥5499
- Biorbyt
- 英国
- orb1714179
- 2026年08月07日
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- 文献和实验
- 技术资料
- 保存条件：
详询
- 保质期：
12 months from date of receipt.
- 英文名：
Geldanamycin: Biotin
- 库存：
99
- 供应商：
Biorbyt
- CAS号：
30562-34-6
- 规格：
1 mg
描述: Hsp90 inhibitor
别名: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
形态: Purple Solid
分子式: C55H87N7O17S
危险信息: Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects
分子量: 560.6
纯度: >98%
SMILES: C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)\C)C)O)OC
溶解度: Soluble in DMSO
来源: Synthetic
保存条件: -20°C
备注: For research use only.
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文献和实验Assays for HSP90 and Inhibitors
of HSP90 inhibitors have already been identified. These include the benzoquinone ansamycin natural product geldanamycin and its analog, 17-allylamino-17-demethoxy-geldanamycin (17AAG), together with the chemically dissimilar natural product radicicol
GPC Spin Column HPLCESI-MS Methods for Screening Drugs Noncovalently Bound to Proteins
are fully described. The GPC spin column HPLC–ESI-MS methodology for screening of drugs non-covalently bound to proteins is illustrated for the non-covalent binding of geldanamycin with Hsp90cat protein.
More Than One Way to Die: Methods to Determine TNF-Induced Apoptosis and Necrosis
apoptotically, because triggering of Fas in L929sAhFas cells leads to apoptosis. Moreover, TNFR-1-induced necrosis can be reverted to apoptosis when cells are pretreated with geldanamycin, an Hsp90 inhibitor. In contrast, addition of caspase-inhibitors (zVAD-fmk
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