重组人外切酶体成分9(EXOSC9)

产品英文名称：
Recombinant Human Exosome Component 9

英文简称:
EXOSC9

中文名称:
重组人外切酶体成分9

背景资料:
EXOSC9 is a non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and take part in many cellular RNA processing and degradation events. In the nucleus， the RNA exosome complex take part in proper maturation of stable RNA species like rRNA， snRNA and snoRNA， in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts like anti-sense RNA species and promoter-upstream transcripts （PROMPTs）， and of mRNAs with processing defects， thereby limiting or excluding their export to the cytoplasm. The RNA exosome is involved in Ig class switch recombination （CSR） and/or Ig variable region somatic hypermutation （SHM） by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm， the RNA exosome complex takes part in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements （AREs） within their 3’ untranslated regions， and in RNA surveillance pathways， inhibiting translation of aberrant mRNAs. EXOSC9 takes part in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits （Exo-9） is proposed to be an essential part in the binding and presentation of RNA for ribonucleolysis， and acts as a scaSf9 昆虫细胞重组表达old for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.

产品描述:
EXOSC9 is a Full-length cDNA coding for the human PM/Scl 75c-beta isoform having a molecular mass of 64 KDa. EXOSC9 protein is fused to a hexa-histidine purification tag.
来源宿主:
Sf9 昆虫细胞重组表达

溶解建议:
提供的重组人外切酶体成分9产品形式为经无菌过滤处理的无色溶液.

保存建议：
重组人外切酶体成分9产品在4℃保存请2 - 4周内将使用；-20℃可长期保存.避免反复冻融.
应用领域：
重组人外切酶体成分9产品可广泛应用于酶活性研究、代谢研究、功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。

关键词：
重组人外切酶体成分9、Recombinant Human Exosome Component 9、EXOSC9、重组蛋白、酶类、昆虫细胞表达、标签蛋白、CMBIO

其他简介：

 
CMBIO