重组人原肌球蛋白-1(TPM1)

产品英文名称：
Recombinant Human Tropomyosin-1

英文简称:
TPM1

中文名称:
重组人原肌球蛋白-1

背景资料:
TPM1 is a member of the tropomyosin family which consists of a number of extremely conserved， extensively distributed 35-45 kDa actin-binding proteins that are involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin-1 is composed of 2 alpha-helical chains arranged as a coiled-coil. TPM1 is polymerized end to end alongside the two grooves of actin filaments and provides stability to the filaments. TPM1 binds to actin filaments in muscle and non-muscle cells. TPM1 also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In non-muscle cells TPM1 is implicated in stabilizing cytoskeleton actin filaments. Smooth muscle contraction is controlled by interaction with caldesmon. Alternatively spliced transcript variants encoding a range of isoforms have bTPM1 Human Recombinant produced in E.Coli is single， a non-glycosylated， Polypeptide chain containing 284 amino acids fragment corresponding to the mature full length variant 3 protein， having a total molecular mass of 40kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The TPM1 is purified by proprietary chromatographic techniques.n described in smooth muscle and non-muscle cells. TPM1 Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues， with higher expression levels in the cardiac tissues， whereas Isoform 10 is expressed in adult and fetal cardiac tissues， but not in skeletal muscle. Mutations in the TPM1 gene are linked to type 3 familial hypertrophic cardiomyopathy.

产品描述:
TPM1 Human Recombinant produced in E.Coli is single， a non-glycosylated， Polypeptide chain containing 284 amino acids fragment corresponding to the mature full length variant 3 protein， having a total molecular mass of 40kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The TPM1 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

溶解建议:
Sterile Filtered clear solution. TPM1 protein is supplied in 1x PBS and 50% glycerol.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. Please avoid freeze thaw cycles.
应用领域：
重组人原肌球蛋白-1产品可广泛应用于功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。

关键词：
重组人原肌球蛋白-1、Recombinant Human Tropomyosin-1、TPM1、重组蛋白、多肽、原核表达、标签蛋白、CMBIO

其他简介：

 
CMBIO