重组小鼠CXC趋化因子配体16(mCXCL16)

产品英文名称：
Recombinant Mouse CXCL16

英文简称:
mCXCL16

中文名称:
重组小鼠CXC趋化因子配体16

背景资料:
Mouse CXCL16 is a nonELR motif including CXC chemokine with a transmembrane domain. Mouse CXCL16 cDNA encodes a 246 a.a. precursor protein with a putative 26 a.a. residue signal peptide， an 88 a.a. residue chemokine domain， an 87 a.a. residue mucinlike spacer region， a 22 a.a. residue transmembrane domain， and a 23 a.a. residue cytoplasmic tail. CXCL16 induces a strong chemotactic response and calcium mobilization. Furthermore， CXCL16 acts as a scavenger receptor on macrophages， which specifically binds to OxLDL （oxidized low density lipoprotein）， suesting that it may be involved in pathophysiology such as atherogenesis. Mouse CXCL16 is generated by dendritic cells in lymphoid organ T cell zones as well as by cells in the splenic red pulp both as membranebound and soluble forms. CXCR6/Bonzo （STRL33 and TYMSTR） is the receptor for CXCL16. CXCL16 is expressed in the spl小鼠CXC趋化因子配体16重组蛋白是在大肠杆菌中重组表达的，是一条单链、非糖基化的多肽链，包含有88个氨基酸，分子量为9.9kDa.该小鼠CXC趋化因子配体16重组蛋白最终由标准的色谱技术纯化出.n， lymph nodes， and Peyer patches. It is also expressed in non-lymphoid tissues such as lung， kidney， small intestine， and thymus， with weak expression in heart and liver and no expression in brain and purified B- and T-cells. CXCL16 deficiency is linked to breast cancer progression. In addition， CXCL16 is involved in immunological liver injury by regulating T lymphocyte infiltration in liver tissue. Furtheremore， CXCL16 has a distinctive role in the maintenance of cardiac allograft tolerance mediated by natural killer T cells. Moreover， CXCL16 has a significant role in not only the production of IFN-gamma by NKT cells， but also promotion of Th1-inclined immune responses mediated by NKT cells.

产品描述:
小鼠CXC趋化因子配体16重组蛋白是在大肠杆菌中重组表达的，是一条单链、非糖基化的多肽链，包含有88个氨基酸，分子量为9.9kDa.该小鼠CXC趋化因子配体16重组蛋白最终由标准的色谱技术纯化出.
来源宿主:
大肠杆菌中重组表达

溶解建议:
提供的小鼠CXC趋化因子配体16（mCXCL16）产品为过滤灭菌的白色冻干粉末；该冻干粉末是从含1.0mg/ml小鼠CXC趋化因子配体16（mCXCL16）的20mM PB（pH 7.4）， 50mM NaCl溶液中冻干产生的.我们建议加无菌的18MΩ-cm水以配制工作储存液到不低于100ug/ml，后继实验过程中可根据实验要求进一步稀释.

保存建议：
小鼠CXC趋化因子配体16（mCXCL16）冻干粉末在室温可保存3周，或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天；如果想延长保存时间，建议分装（加载体蛋白如0.1% HSA或 BSA）后置于-18℃冻存.请避免反复冻融.
应用领域：
重组小鼠CXC趋化因子配体16产品可广泛应用于炎症研究、免疫细胞迁移研究、信号传导研究、药物靶点研究、功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。

关键词：
重组小鼠CXC趋化因子配体16、Recombinant Mouse CXCL16、mCXCL16、重组蛋白、多肽、趋化因子、受体蛋白、原核表达

其他简介：

 
CMBIO