C1QA Antibody / Complement C1q

类别: Antibodies

产品子类型: Primary Antibody

描述: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.

克隆号: C1QA/2953

应用稀释比例: Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml

应用说明: Optimal dilution of the C1QA antibody should be determined by the researcher.

免疫原: A recombinant human partial protein (amino acids 104-237) was used as the immunogen for the C1QA antibody.

防腐剂: 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide

纯化方法: Protein G affinity chromatography

研究领域: Immunology & Inflammation

UniProt ID: P02745

保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

备注: For research use only.