DiagSupport™ 3-Aminopropyl Sil

Amine Silica Particles are effective scavengers of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Researchers compared PS-Triamine to Amine Silica Particles for the removal of acid chlorides in the synthesis of 2,9-disubstituted guaninies. Using Amine Silica Particles to remove excess acid chloride gave higher yields and better purity in more than 93% compared to PS-Trisamine. Amine Silica Particles eliminate tedious post reaction purification. They work faster, are easier to add and filter, and can be used in any solvent. Amine Silica Particles have been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. They have also been used as support in solid-phase chemistry for peptide synthesis followed by enzymatic hydrolysis and for Claisen rearrangement. They are best scavengers for Cd, Cr, Pd and Rh, good scavenger for Co, Cu, Fe, Hg, Pb, W and Zn. Amine Silica Particles are also used in chromatography as normal phase sorbent. They are used in the preparation of peptides, drugs and metabolites from physiological fluids and for the separation of mono- and polysaccharides. They are more retentive towards basic compounds. When used at pH≤ 7.8, they are protonated and may be used as a weak anion exchanger. Amine Silica Particles have been used for the solid-phase extraction of sugars, for the separation of steroids, cholesterol, and triglycerides, and in size exclusion chromatography of cationic polymers. They are non-endcapped for additional retention of polar and cationic compounds.