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- 文献和实验
- 技术资料
- 免疫原:
inquire
- 亚型:
Human IgG4 - Kappa
- 形态:
Powder
- 保存条件:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 级别:
Research use only
- 库存:
In Stock
- 供应商:
缔码生物(武汉)科技有限公司
- 宿主:
Humanized
- 应用范围:
Flow Cyt
- 浓度:
详见COA
- 靶点:
ITGA4
- 抗体英文名:
Anti-ITGA4 (natalizumab biosimilar) mAb
- 抗体名:
Anti-ITGA4 (natalizumab biosimilar) mAb
- 规格:
50μg
| 产品类型 | Biosimilar reference antibodies |
|---|---|
| 靶点 | ITGA4 |
| Uniprot ID | P13612 |
| 背景 | Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals. |
| 通用名 | AN100226,AN100226,BG00002 |
| 货期 | In Stock |
| 产品英文名称 | Anti-ITGA4 (natalizumab biosimilar) mAb |
| 内毒素 | Less than 1.0 EU/μg by the LAL method. For <1 EU/mg requirements, please contact us for customization. |
| 保质期 | 12 months from date of dispatch |
| 无菌性 | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| 别名 | CD49D;IA4 |
| 应用 | Flow Cyt |
| 有无偶联 | Unconjugated |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 宿主种属 | Humanized |
| IgG亚型 | Human IgG4 - Kappa |
| 反应种属 | Human |
| 推荐稀释比 | Flow Cyt 1:10 |
| 应用范围 | Research use only |
Figure 1. Anti-ITGA4 (natalizumab biosimilar) mAb on SDS-PAGE under non-reducing (NR) and reducing (R) conditions.
Figure 1. Flow cytometry analysis with 15 μg/mL Anti-ITGA4 (natalizumab) mAb (BME100074) on HEK293 cells transfected with Human ITGA4 protein (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验ITGA4(CD49D)信号通路、病理作用与靶向治疗药物研究梳理
的淋巴细胞穿越血脑屏障是疾病发展的关键环节,靶向该分子的疗法(如Natalizumab)已证实有效。在炎症性肠病(IBD)中,ITGA4与β7亚基形成的异二聚体(α4β7)引导淋巴细胞归巢至肠道黏膜,加剧炎症反应,使其成为克罗恩病和溃疡性结肠炎的重要治疗靶点。此外,ITGA4的异常表达还参与多种恶性肿瘤的进展,如慢性淋巴细胞白血病(CLL)中T细胞表面CD49D(ITGA4)的高表达与疾病预后相关,以及卵巢癌中ITGA4/ITGB2复合物促进腹膜转移,凸显其在肿瘤侵袭和转移中的作用。 ITGA4
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