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- CAS号：
202409-33-4
- 规格：
1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥124.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥110.0 |
| 规格： | 10mg | 产品价格： | ￥173.0 |
| 规格： | 25mg | 产品价格： | ￥269.0 |
| 规格： | 50mg | 产品价格： | ￥368.0 |
| 规格： | 100mg | 产品价格： | ￥633.0 |
| 规格： | 500mg | 产品价格： | ￥1592.0 |
Product Introduction
Bioactivity
| 名称 | Etoricoxib |
| 描述 | Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. |
| 细胞实验 | Human colon carcinoma cell line HCT-116 are treated with various coxibs for 2 h. Subsequently, the cells are harvested and the sphingolipids isolated and determined by LC-MS/MS. (Only for Reference) |
| 体内活性 | 环氧合酶-2抑制剂etoricoxib显著降低了phenytoin的抗惊厥作用，并显著增强了diazepam对小鼠模型中最大电休克和戊四氮诱导的惊厥的有益作用[1]。Etoricoxib有作为结肠抗凋亡和抗增殖剂的潜力[2]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Ethanol : 43 mg/mL (119.83 mM), Sonication is recommended. DMSO : 252 mg/mL (702.26 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (13.93 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 关键字 | MK663 | MK-0663 | MK0663 | MK 663 | MK 0663 | L791456 | L 791456 | Inhibitor | inhibit | Etoricoxib | Cyclooxygenase | COX |
| 相关产品 | Trometamol | Gallic Acid Monohydrate | Naproxen sodium | 4-Aminosalicylic acid | 5-Methylfurfural | Phenylbutazone | Indomethacin | Paradol | Acetaminophen | Diclofenac Potassium | Magnesium sulfate | Phenidone |
| 相关库 | Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compound Library | Anti-Cancer Active Compound Library | Bioactive Compounds Library Max | EMA Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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依托考昔【202409-33-4】
￥110 - 1592
