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- T6969
- 2026年07月07日
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- CAS号：
138261-41-3
- 规格：
1mLx10mM(inDMSO)/50mg/100mg/200mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥164.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥250.0 |
| 规格： | 100mg | 产品价格： | ￥332.0 |
| 规格： | 200mg | 产品价格： | ￥543.0 |
Product Introduction
Bioactivity
| 名称 | Imidacloprid |
| 描述 | Imidacloprid is a systemic chloronicotinyl insecticide, which can be effectively used in agriculture to control pests . |
| 体外活性 | Three different cell models were used;?adipocytes (3T3-L1), hepatocytes (HepG2), and myotubes (C2C12).?These cells were treated with imidacloprid (0, 10, and 20 μM) for 4-6 days followed by treatment with insulin for 15 min to determine responses.?Insulin stimulated glucose uptake was reduced by imidacloprid in all three cell culture models.?Treatment with imidacloprid reduced phosphorylation of protein kinase B (AKT), one of the major regulators of insulin signaling, without changing overall AKT expression.?Subsequently, imidacloprid reduced phosphorylation of ribosomal S6 kinase (S6K), which is a downstream target of AKT and also a feed-back inhibitor of insulin signaling.?Suggest that imidacloprid could induce insulin resistance by affecting the insulin signaling cascade, particularly up-stream of AKT, in adipocytes, liver, and muscle[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 250 mg/mL (977.86 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (19.56 mM), Sonication is recommended. |
| 关键字 | Inhibitor | inhibit | Imidacloprid |
| 相关库 | Bioactive Compound Library | Bioactive Compounds Library Max | ReFRAME Related Library | EMA Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | NO PAINS Compound Library | Animal Drug Library | Covalent Inhibitor Library | Human Metabolite Library | Pesticide Compound Library |
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吡虫啉【138261-41-3】
￥164 - 543
