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- 技术资料
- CAS号：
298197-04-3
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg/200mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥392.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥172.0 |
| 规格： | 5mg | 产品价格： | ￥362.0 |
| 规格： | 10mg | 产品价格： | ￥527.0 |
| 规格： | 25mg | 产品价格： | ￥952.0 |
| 规格： | 50mg | 产品价格： | ￥1584.0 |
| 规格： | 100mg | 产品价格： | ￥2496.0 |
| 规格： | 200mg | 产品价格： | ￥3744.0 |
| 规格： | 500mg | 产品价格： | ￥5576.0 |
Product Introduction
Bioactivity
| 名称 | Fatostatin hydrobromide |
| 描述 | Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2. |
| 细胞实验 | Cell lines: CHO-K1 cells. Concentrations: 20 μM. Incubation Time: 20 h. Method: On day 0,CHO-K1 cells are plated out onto a 96-well plate in medium A.On day 2,the cells are transiently cotransfected with pCMV-PLAP-BP2(513–1141),pCMV-SCAP,and pAc-β-gal,using Lipofectamine reagent.After incubation for 5 hr,the cells are washed with PBS and then incubated in medium B,in the absence or presence of fatostatin (20 μM) or sterols (10 μg/mL cholesterol and 1 μg/mL 25-hydroxycholesterol).After 20 hr of incubation,an aliquot of the medium is assayed for secreted alkaline phosphatase activity.The cells in each well are lysed and used for measurement of β-galactosidase activities.The alkaline phosphatase activity is normalized by the activity of β-galactosidase. |
| 动物实验 | Animal Models: Obese (ob/ob) mice (C57BL/6J background). Formulation: 10% DMSO in PBS. Dosages: 30 mg/kg. Administration: intraperitoneal injection |
| 体外活性 | Fatostatin inhibits the insulin-induced adipogenesis of 3T3-L1 cells and the serum-independent growth of human androgen-independent prostate cancer (DU145) cells. Fatostatin suppresses cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. Fatostatin blocks the activation of SREBPs in cells in tissue culture.Fatostatin also reduced in vitro invasion and migration in both cell lines. Further, fatostatin causes G2/M cell cycle arrest and induces apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP. |
| 体内活性 | Fatostatin significantly inhibits subcutaneous C4-2B tumor growth and markedly decreases serum PSA level compared to the control group. Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.66 mM), Sonication is recommended. DMSO : 17.86 mg/mL (47.58 mM), Sonication is recommended. Ethanol : 58 mg/mL (154.53 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 关键字 | SREBPs | SREBP-mediated | ob/ob | mice | insulin-induced | Golgi | gene | FattyAcidSynthase | Fatty Acid Synthase (FASN) | Fatty Acid Synthase | expression | adipogenesis | 125B11 |
| 相关产品 | α-Lipoic Acid sodium | A-769662 | Coenzyme A | Lycorine | trans-Chalcone | Orlistat | Ezetimibe | Betulin | Pyrazinamide | 2-Octanone | L-Carnitine | Maltitol |
| 相关库 | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Metabolism Compound Library | Metabolism Compound Library | NO PAINS Compound Library | Anti-Obesity Compound Library | Multi-Target Compound Library | Membrane Protein-targeted Compound Library |
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化合物 Fatostatin【298197-04-3】
￥172 - 5576
