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- 2026年07月07日
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- 文献和实验
- 技术资料
- CAS号：
2409963-83-1
- 规格：
1mLx10mM(inDMSO)/2mg/5mg/25mg/50mg/100mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥2776.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥1696.0 |
| 规格： | 5mg | 产品价格： | ￥2648.0 |
| 规格： | 25mg | 产品价格： | ￥8480.0 |
| 规格： | 50mg | 产品价格： | ￥11040.0 |
| 规格： | 100mg | 产品价格： | ￥14000.0 |
Product Introduction
Bioactivity
| 名称 | LOX-IN-3 |
| 描述 | LOX-IN-3, an orally active inhibitor of lysyl oxidase (LOX), holds potential application in the fields of fibrosis, cancer, and angiogenesis research[1]. |
| 体外活性 | LOX-IN-3 (Compound 33) inhibits the bovine LOX and human LOXL2 activities with IC50 values of <10 μM and <1 μM, respectively. LOX-IN-3 is less active against SSAO/VAP-1 and MAO-B activities[1]. |
| 体内活性 | In young male Wistar rats, a single high (30 mg/kg) dose of LOX-IN-3 (Compound 33) completely abolishes lysyl oxidase activity. While plasma concentrations of LOX-IN-3 are far below the IC50 after 8 hours, the half-life of recovery is between 2-3 days (ear) and 24 hours (aorta)[1].In a 14-day unilateral ureteric obstruction (UUO) model, LOX-IN-3 (Compound 33, 10 mg/kg daily; orally) treatment increases kidney weight and thickness and reduces the area of fibrosis as measured by Picrosirius Red[1].In BALB/c mice bearing hepatic fibrosis, LOX-IN-3 (Compound 33, 20 mg/kg daily, i.p.) treatment significantly reduces liver fibrosis. At the end of week 4 a mouse breast cancer cell line (4tl) is injected orthotopically. LOX-IN-3 (Compound 33) treatment significantly reduces liver fibrosis, collagen cross-links and the metastatic load in the liver[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (11.77 mM), Sonication is recommended. DMSO : 125 mg/mL (445.92 mM), Sonication is recommended. |
| 关键字 | LOX-IN-3 | LOXIN3 | LOX IN 3 |
| 相关产品 | Amitraz | β-Aminopropionitrile | Safinamide | 1,4-Naphthoquinone | Hydroxylamine hydrochloride | Methylene Blue | Methylene Blue trihydrate | Phenelzine sulfate | Isatin | D-(-)-Quinic acid | Aminoacetone hydrochloride | Paeonol |
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文献和实验Developing Genetically Engineered Mouse Models to Study Tumor Suppression
step introduces three lox P sites (red ovals) and a neo‐tk gene by homologous recombination into the p 53 locus. Cre‐mediated deletion of neo and not deletion of the entire p 53 gene is possible when Cre is weakly expressed. The Trp53F2‐10 allele
Overexpression Models: Lentiviral Modeling of Brain Cancer
is described here. In this approach, a lenti?vector with lox P sites flanking the gene of interest (oncogene) is injected into mice expressing Cre recombinase under the control of a brain?specific promoter. The steps to perform cell?type/region?specific
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