- ￥1864 - 12240
- TargetMol
- T72771
- 2026年07月07日
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- 技术资料
- CAS号：
2849340-59-4
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥5408.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥1864.0 |
| 规格： | 5mg | 产品价格： | ￥4504.0 |
| 规格： | 10mg | 产品价格： | ￥6304.0 |
| 规格： | 25mg | 产品价格： | ￥9360.0 |
| 规格： | 50mg | 产品价格： | ￥12240.0 |
Product Introduction
Bioactivity
| 名称 | p53 Activator 7 |
| 描述 | p53 Activator 7 is a highly potent and cell-permeable activator of the p53 mutation Y220C (MDM-2/p53), which induces apoptosis. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.39 mM), Sonication is recommended. DMSO : 80 mg/mL (154.88 mM), Sonification is recommended. |
| 关键字 | MDM-2/p53 | Apoptosis |
| 相关产品 | Formamide | Urea | Sodium Molybdate | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Citric Acid Triammonium | Stavudine | Tamoxifen |
| 相关库 | Bioactive Compound Library | Bioactive Compounds Library Max | Anti-Pancreatic Cancer Compound Library | Fluorochemical Library | Apoptosis Compound Library | Anti-Aging Compound Library |
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文献和实验小红赛 我目前在做药物靶向治疗肿瘤的课题，想在肿瘤细胞水平上以P53—MDM2为靶点，研究阻断MDM2或阻止P53水解时的信号变化及对细胞生长的影响，但目前不知道在P53—MDM2这个靶点上，有什么好的药物或者抑制剂，能用于细胞水平研究的，谢谢 selleckchem01 在这个靶点 下面两个抑制剂都可以用于细胞试验~ Nutlin-3 Nutlin-3 is a MDM
Knowledge-Based Virtual Screening: Application to the MDM4/p53 ProteinProtein Interaction
or conserved molecular recognition. Herein, we demonstrate the potential of knowledge-based virtual screening by applying it to the MDM4-p53 protein–protein interaction where the MDM2-p53 protein–protein interaction constitutes the parent reference
Abrogation of p53-Induced Apoptosis by the Hepatitis B Virus X Gene
, as an oncoprotein, HBx has been reported to disregulate cell-cycle transition (14 ,15 ) to potentially target certain proteases and proteasome (16 –18 ), to interact with DNA repair factors (19 ,20 ), or to interact with the p53 tumor suppressor gene product
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