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货期：1-2天
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MedChemExpress LLC
- CAS号：
2849340-59-4
- 规格：
10 mM * 1 mL///1 mg
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p53 Activator 7
CAS No. : 2849340-59-4
MCE 国际站：p53 Activator 7
产品活性：p53 Activator 7 是一种 p53 突变 Y220C (MDM-2/p53) 激活剂，EC50 为 104 nM。p53 Activator 7 可以结合 p53 突变体并恢复其结合 DNA 的能力 (WO2022213975A1; Example B-1)。
研究领域：Apoptosis
作用靶点：MDM-2/p53
In Vitro: The p53 protein, referred to as the “guardian of the human genome” , is a tetrameric transcription factor that prevents mutation to the genome by regulating the expression of a subgroup of target genes. Although biologically active as a homotetramer, each p53 monomer is comprised of 393 amino acids, and is divided into five key regulatory domains: the transactivation domain (TAD) , proline-rich region (PR) , the DNA binding domain (DBD) , the oligomerization domain (OD) , and the C-terminus.
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文献和实验Methods to Study p53-Repressed Promoters
There is substantial evidence in the literature that, in addition to functioning as an activator of transcription, the p53 tumor suppressor protein can also function as a sequence-specific transcriptional repressor of a separate set of genes
in nude mice by 90% at a dose of 200 mg/kg。 NSC-207895 (XI-006) NSC-207895 (XI-006), also called a small-molecule p53 activator, gives rise to MCF-7 cells to experience apoptosis and decrease the viability of cancer cells
Electrophoretic Mobility Shift Analysis of the DNA Binding of Tumor Suppressor Gene Products
is further highlighted by the fact that the major sites of mutation found in human cancers are localized to this region (12 ). Several of these mutations have been shown to abolish the ability of p53 to function as a transcriptional activator (13 –15 ). A DNA
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