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- 2026年07月07日
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- CAS号：
18642-44-9
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥3824.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥1344.0 |
| 规格： | 5mg | 产品价格： | ￥2984.0 |
| 规格： | 10mg | 产品价格： | ￥4264.0 |
| 规格： | 25mg | 产品价格： | ￥6304.0 |
| 规格： | 50mg | 产品价格： | ￥8640.0 |
Product Introduction
Bioactivity
| 名称 | Actein |
| 描述 | Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways involved in lipid disorders and carcinogenesis may make it a new agent for preventing and treating these major disorders, it has been shown to inhibit the proliferation of human breast cancer cells, by altering the activity of the ER IP3 receptor and Na,K-ATPase, inducing calcium release and modulating the NF-kB and MEK pathways. |
| 体外活性 | Actein（从黑升麻中分离出来）经过体外实验，研究其在成骨细胞MC3T3-E1中的功能性生物活性。方法和结果表明，Actein显著提高了细胞中的碱性磷酸酶活性、胶原蛋白合成、骨钙蛋白产生、矿化以及谷胱甘肽含量，暗示Actein对成骨骨形成具有刺激作用或对抗骨质疏松症具有潜在活性。我们还研究了Actein对线粒体电子传递抑制剂Antimycin A诱导的成骨细胞MC3T3-E1细胞毒性的保护效果。MC3T3-E1细胞暴露于Antimycin A会显著降低细胞活性和矿化。然而，Antimycin A暴露前的Actein预处理显著减少了Antimycin A诱导的细胞损伤，通过防止线粒体膜电位消散、复合体IV失活、心磷脂氧化、ROS释放和酪氨酸硝化物增加，暗示Actein可用于保护线粒体免受氧化应激的突发。此外，Actein增加了由Antimycin A抑制的CREB（cAMP应答元件结合蛋白）的磷酸化，并减少了由Antimycin A诱导的TNF-α产生。结论：这些发现表明Actein能够预防骨质疏松症患者中成骨细胞的氧化损伤。 |
| 存储条件 | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 60 mg/mL (88.65 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2.5 mg/mL (3.69 mM), Sonication is recommended. |
| 关键字 | TNF-α | Sodium Channel | Protein kinase B | Potassium Channel | PKB | p53 | NF-κB | MEK | JNK | Inhibitor | inhibit | CYP17 | cAMP | Autophagy | ATPase | Apoptosis | Akt | Actein |
| 相关产品 | Formamide | Allopurinol | Kaolin | Guanidine hydrochloride | Aceglutamide | Alginic acid | Hemin | Hydroxychloroquine | Stavudine | Ethoxyquin | Paeonol | Ethyl linoleate |
| 相关库 | Bioactive Compound Library | Anti-Cancer Active Compound Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Kinase Inhibitor Library | Anti-Tumor Natural Product Library | Anti-Aging Compound Library | Rare Natural Product Library | Traditional Chinese Medicine Monomer Library | Immunology/Inflammation Compound Library | Terpene Natural Product Library |
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黄肉楠碱【18642-44-9】
￥1344 - 8640
