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- 文献和实验
- 技术资料
- CAS号：
469-59-0
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥556.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥244.0 |
| 规格： | 5mg | 产品价格： | ￥534.0 |
| 规格： | 10mg | 产品价格： | ￥984.0 |
| 规格： | 25mg | 产品价格： | ￥1584.0 |
| 规格： | 50mg | 产品价格： | ￥2496.0 |
| 规格： | 100mg | 产品价格： | ￥3592.0 |
| 规格： | 200mg | 产品价格： | ￥5032.0 |
Product Introduction
Bioactivity
| 名称 | Jervine |
| 描述 | The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed. |
| 细胞实验 | Cells are grown in Eagle's basal medium supplemented with 10% fetal bovine serum and 0.25 mg/ml gentamicin sulfate. Cells are seeded onto 35-mm tissue culture plates at a density of 1×104 celldplate. The plated cells are incubated for 24 hours prior to treatment in a humidified incubator at 37 "C in an atmosphere of 5% CO2 in air. Drugs are then added: jervine to a final concentration of 5, 10, or 25 μg/ml; retinoic acid at 0.03, 0.30, or 3.0 pg/ml. After a final 48 hours of incubation, media are removed, the cultures are rinsed three times with phosphate-buffered saline (PBS) pH 7.4, and the cells are harvested into 0.5 ml of 0.1% (w/v) trypsin which contained 0.1% EDTA (w/v) in PBS. Each sample is mixed with 9.5 ml Isoton Ⅱ, and cell numbers are determined by using a Coulter Counter. (Only for Reference) |
| 体外活性 | 与对照组相比，暴露于25 μg/ml jervine的软骨细胞培养显示细胞数量明显减少，但在细胞形态或alcian blue染色的相对强度上没有差异[2]。 |
| 体内活性 | 胚胎暴露于jervine时，会发展出与Shh突变胚胎中发现的类似的颅面异常。这些胚胎的下颌严重缩小，常常导致门牙缺失。用jervine处理怀孕的小鼠，会在胚胎中诱发类似于Prx1/Prx2/胚胎中发现的下颌缺陷。下颌的远端部分大小减小，两颗门牙缺失[1]。 |
| 存储条件 | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Chloroform : Soluble H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 4.26 mg/mL (10.01 mM), Sonication is recommended. |
| 关键字 | Veratrum | teratogenic | sterodial | Smoothened | Smo | rhizomes | Jervine | Inhibitor | inhibit | Hedgehog | antioxidant | anti-inflammatory | alkaloid | album |
| 相关产品 | ALLO-2 | 5-LOX inhibitor | Halcinonide | Triparanol | Ellagic acid | MRT-83 | Naftifine hydrochloride | GANT 61 | Vismodegib | IHR-1 | RU-SKI 43 | Itraconazole |
| 相关库 | Inhibitor Library | Selected Plant-Sourced Compound Library | Alkaloid Natural Product Library | Miao medicine Compound Library | Anti-Tumor Natural Product Library | Anti-Aging Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library | GPCR Compound Library | Membrane Protein-targeted Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS |
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文献和实验的固有成分，如C1-C9、B、D、P因子及MBL相关蛋白，分别参与经典、旁路或凝集素途径，其中C5-C9为共同终末通路分子；二是补体调节蛋白，以可溶或膜结合形式控制活化程度，如C1INH、H因子、DAF、CD59等；三是补体受体，包括CR1-CR5、C3aR、C5aR等，介导补体片段的生物学效应。 补体激活途径 补体系统可通过三条主要途径激活：经典途径、旁路途径和凝集素途径。经典途径由抗原-抗体复合物触发，C1q识别并结合免疫球蛋白（IgM或IgG）的Fc段，在Ca²⁺依赖下激活C1r和C1
518.8 46.43 485.59～552.01 41 495.9 36.89 469.53～522.27 42 °526.4 42.78 495.80～557.00 43 505.8 53.84 467.30～544.30
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