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- CAS号：
6882-68-4
- 规格：
1mLx10mM(inDMSO)/20mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥152.0 |
|---|---|---|---|
| 规格： | 20mg | 产品价格： | ￥102.0 |
Product Introduction
Bioactivity
| 名称 | Sophoridine |
| 描述 | Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 250 mg/mL (1006.6 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.05 mM), Sonication is recommended. 10% DMSO+90% Saline : 10 mg/mL (40.26 mM), Solution. |
| 关键字 | Topo I | Sophoridine | Inhibitor | inhibit | Apoptosis |
| 相关产品 | Formamide | Urea | Sodium Molybdate | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Citric Acid Triammonium | Stavudine | Tamoxifen |
| 相关库 | Anti-Cancer Approved Drug Library | Bioactive Compound Library | Anti-Cancer Active Compound Library | Anti-Tumor Natural Product Library | Anti-Aging Compound Library | Natural Product Library | Anti-Viral Compound Library | Traditional Chinese Medicine Monomer Library | Anti-virus Traditional Chinese Medicine Monomer Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library |
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文献和实验该产品被引用文献
官网有文献
相关实验
医学・中医中药分册，1996，18（4）：7. ［2］陈发奎.常用中草药有效成分含量测定［M］.北京：人民卫生出版社， 1997：396. ［3］张中苏，张林英，王润生，等.苦参薄层色谱法的改进［J］.中国中药杂志，1995，20（3）：171. ［4］张爱华，张悦晗，陈新菊，等.反相高效液相色谱法测定槐定碱原料及注射液的含量［J］.中国新药杂志，2007，16（1）：68.
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槐定碱【6882-68-4】
￥102 - 152
