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- 2026年07月07日
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- 文献和实验
- 技术资料
- CAS号：
568-73-0
- 规格：
1mg/5mg/10mg/25mg/50mg/100mg/500mg
| 规格： | 1mg | 产品价格： | ￥102.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥198.0 |
| 规格： | 10mg | 产品价格： | ￥280.0 |
| 规格： | 25mg | 产品价格： | ￥442.0 |
| 规格： | 50mg | 产品价格： | ￥650.0 |
| 规格： | 100mg | 产品价格： | ￥928.0 |
| 规格： | 500mg | 产品价格： | ￥2216.0 |
Product Introduction
Bioactivity
| 名称 | Tanshinone I |
| 描述 | Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells. |
| 细胞实验 | RAW 264.7 cells are cultured with DMEM supplemented with 10% FBS and 1% antibiotics under 5% CO2 at 37°C. Briefly, cells are plated in 96-well plates (2×105 cells/well). LPS (1 ug/mL) and Tanshinone I are simultaneously added and incubated for 24 h, unless otherwise specified. The PGE2 concentration in the medium is measured using an EIA kit for PGE2. In order to determine the effects of Tanshinone I on PGE2 production after induction of COX-2, cells are incubated with LPS (1 ug/mL) for 24 h and thoroughly washed. Then, Tanshinone I is added without LPS and the cells are incubated for another 24 h. From the medium, PGE2 concentrations are measured. The cytotoxicity of Tanshinone I to RAW cells is checked using the MTT assay. Tanshinone I does not show any cytotoxicity up to 100 uM[1]. |
| 激酶实验 | As sources of PLA2, human recombinant sPLA2 (type IIA) is purified from CHO cells transfected with the PLA2 gene and rabbit recombinant platelet cPLA2 is obtained through its expression in baculovirus. The standard reaction mixture (200 μL) contained 100 mM Tris-HCl buffer (pH 9.0) with 6 mM CaCl2 and 20 nmol 1-acyl-[1-14C]-arachidonyl-sn-glycerophosphoethanolamine (2000 cpm/nmol) in the presence or absence of Tanshinone I. The reaction is started by adding 50 ng purified sPLA2 or cPLA2. After 20 min at 37°C, the free fatty acid generated is analysed. Under these standard conditions, the reaction mixture in the absence of Tanshinone I released approximately 10% of free fatty acid from the phospholipid substrate added[1]. |
| 体内活性 | Tanshinone I在大鼠肉胶原（CGN）诱导的爪肿胀和大鼠佐剂诱导性关节炎（AIA）模型中展示了抗炎活性，这些模型是研究急性和慢性炎症的经典动物模型。口服Tanshinone I对CGN诱导的爪肿胀表现出显著的抗炎活性（160 mg/kg时，抑制率为47%），而indomethacin的IC50为7.1 mg/kg。在AIA模型中，Tanshinone I以每日口服50 mg/kg的剂量，在第18天抑制二次炎炎症27%，而prednisolone（每日5 mg/kg）展现出更强的抑制效果（65%）[1]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 2.5 mg/mL (9.05 mM), Sonication is recommended. |
| 关键字 | Tanshinone I | PLA2 | Phospholipase | Inhibitor | inhibit |
| 相关产品 | Difluprednate | Omeprazole | 1-Naphthaleneacetic acid | Indomethacin | 1-Naphthaleneacetic acid potassium salt | Levamisole hydrochloride | Lansoprazole | Benzylideneacetone | Neomycin sulfate | Darapladib | trans-Benzylideneacetone | Magnesium sulfate |
| 相关库 | Bioactive Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | Bioactive Compounds Library Max | Selected Plant-Sourced Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Terpene Natural Product Library | Anti-Cancer Drug Library |
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文献和实验Acids Glycine 75 50 0.667 L-Alanine 89 25 0.281 L-Arginine 211 105 0.498 L-Asparagine-H2O 150 50 0.333 L-Aspartic acid 133 30 0.226 L-Cysteine hydrochloride-H2O 176 100 0.568 L-Cystine 2HCl 313 31 0.0990 L-
secondary antibody review -- data from 99 publications
Laboratories 15 AP western blot 15 rhodamine immunocytochemistry 1:500 15 FITC immunocytochemistry 16 sheep Alexa Fluor 568 immunocytochemistry 1:250 Invitrogen 16 streptavidin-horseradish peroxidase
540.17 52 491.0 58.47 449.18～532.82 53 522.3 65.01 475.79～568.81 54 490.3 49.92 454.58～526.02 55 516.7 37.26 490
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