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- CAS号：
198958-88-2
- 规格：
1mg/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mg | 产品价格： | ￥2368.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥5488.0 |
| 规格： | 10mg | 产品价格： | ￥7544.0 |
| 规格： | 25mg | 产品价格： | ￥11040.0 |
| 规格： | 50mg | 产品价格： | ￥15120.0 |
| 规格： | 100mg | 产品价格： | ￥20400.0 |
Product Introduction
Bioactivity
| 名称 | Elarofiban |
| 描述 | Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist. |
| 体外活性 | Elarofiban (RWJ-53308) is a novel nonpeptide glycoprotein IIb/IIIa (GPIIb/IIIa) antagonist that inhibits fibrinogen binding to GPIIb/IIIa with an IC(50) of 0.4+/-0.3 nM. RWJ-53308 inhibits thrombin-induced platelet aggregation in human gel-filtered platelets (IC(50)=60+/-12 nM) and platelet aggregation in human platelet-rich plasma (PRP) in response to collagen, arachidonic acid, ADP, and SFLLRN-NH(2) (IC(50)=60+/-10, 150+/-30, 70+/-4, and 160+/-80 nM, respectively).[4] |
| 体内活性 | The potency of Elarofiban (RWJ-53308) in dog and guinea pig PRP is similar to human PRP. RWJ-53308 inhibits ex vivo collagen- and ADP-induced platelet aggregation in conscious dogs for up to 4 h following 0.3 mg/kg iv, and through 4 and 6 h following 1 and 3 mg/kg po. Oral bioavailability is 16+/-7%. RWJ-53308 reduces thrombus weight in a canine arteriovenous (AV) shunt model following intravenous (0.01-0.1 mg/kg) and oral (3 mg/kg) administration. In a guinea pig carotid artery pinch-injury model, RWJ-53308 completely suppresses thrombus-induced cyclic flow reductions (CFR) at 0.7 mg/kg iv. RWJ-53308 also blocks thrombus formation in photoactivation- and ferric chloride-induced models of thrombosis in guinea pigs at 0.3 and 1 mg/kg iv, respectively. In summary, RWJ-53308 is a potent orally active GPIIb/IIIa antagonist that may be useful for both acute and chronic treatment of arterial thrombotic disorders.[4] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 60 mg/mL (144.05 mM), Sonication is recommended. |
| 关键字 | GPIIb/IIIa | Elarofiban |
| 相关产品 | Gantofiban | Cucurbitacin B | 2-hydroxy Flutamide | Bestatin hydrochloride | Cyclo(-RGDfK) | (R)-Leucic acid | Elsibucol | ADH-503 | Tirofiban hydrochloride monohydrate | K34c hydrochloride | CLT-28643 | Lifitegrast |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | ReFRAME Related Library | Anti-Cardiovascular Disease Compound Library | Cytoskeletal Signaling Pathway Compound Library | Human Metabolite Library |
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艾罗非班【198958-88-2】
￥2368 - 20400
