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- TargetMol
- T24584
- 2026年07月07日
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- CAS号：
1370261-98-5
- 规格：
1mg/1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mg | 产品价格： | ￥333.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥780.0 |
| 规格： | 5mg | 产品价格： | ￥782.0 |
| 规格： | 10mg | 产品价格： | ￥1216.0 |
| 规格： | 25mg | 产品价格： | ￥2048.0 |
| 规格： | 50mg | 产品价格： | ￥3080.0 |
| 规格： | 100mg | 产品价格： | ￥4312.0 |
| 规格： | 200mg | 产品价格： | ￥5976.0 |
Product Introduction
Bioactivity
| 名称 | P505-15 Acetate |
| 描述 | P505-15 Acetate is a selective inhibitor of spleen tyrosine kinase that acts by suppressing leukocyte immune function and inflammation and leading to a reduction in arthritis score and attenuated histological damage. |
| 体外活性 | In human whole blood, P505-15 potently inhibited B cell antigen receptor-mediated B cell signaling and activation (IC50 0.27 and 0.28 μM, respectively) and Fcε receptor 1-mediated basophil degranulation (IC50 0.15 μM) [1]. P505-15 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL [2]. PRT318 and P505-15 effectively antagonize CLL cell survival after BCR triggering and in nurse-like cell-co-cultures. Moreover, they inhibit BCR-dependent secretion of the chemokines CCL3 and CCL4 by CLL cells, and leukemia cell migration toward the tissue homing chemokines CXCL12, CXCL13, and beneath stromal cells. PRT318 and P505-15 furthermore inhibit Syk and extracellular signal-regulated kinase phosphorylation after BCR triggering [3]. |
| 体内活性 | Similar levels of ex vivo inhibition were measured after dosing in mice (Syk signaling IC50 0.32 μM). Oral administration of P505-15 produced dose-dependent anti-inflammatory activity in two rodent models of rheumatoid arthritis [1]. Oral dosing in mice prevented BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model. In addition, combination treatment of primary CLL cells with P505-15 plus fludarabine produced synergistic enhancement of activity at nanomolar concentrations [2]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 10 mg/mL (22.05 mM), Sonication is recommended. |
| 关键字 | tyrosine kinase | P505-15 Acetate | P-50515 Acetate | P 50515 Acetate |
| 相关产品 | Formamide | Urea | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Citric Acid Triammonium | Stavudine | Tamoxifen | Ethyl linoleate |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Clinical Compound Library | Antioxidant Compound Library | Immunology/Inflammation Compound Library | Tyrosine Kinase Inhibitor Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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文献和实验15 秒止血！MIT 赵选贺团队受自然启发，研制出如此神奇的
Biomed Eng主要研究内容藤壶胶样的生物粘合剂及其止血性能该生物粘合剂由疏水的油性基质和生物黏合剂微粒组成，它们分别与藤壶胶中富含脂质的基质和黏附蛋白具有相似的功能。其形态为可注射的膏状物，借助温和的压力，疏水的油性基质能够排斥血液，从而使压实的生物黏合剂微粒相互作用，并与组织表面彼此交联，在 15 秒内形成牢固的黏附，而不需要额外的辅助。这种排斥交联机制使藤壶胶生物黏合剂具有快速和不依赖体内凝血系统的止血能力。图片来源：Nat Biomed Eng为了研究疏水的油性基质和生物黏合剂微粒对止血的作用
【求助】请问大家一下stk15这个基因一般都是做的那些位点啊
duanshengyu0223 请问大家一下stk15这个基因一般都是做的那些位点啊 侠骨仁医 stk15应该就是Aurora Kinase，目前做的比较多的多态性是T91A F31I Phe31Ile，但是在不同肿瘤和STK15多态性的关联是不一样的，关键看你的研究目的。建议楼主自己好好复习文献，应该可以得到不少启发，附上两篇相关我文献。 duanshengyu0223 嗯，谢谢
伽利略 检RT PCR测到a mRNA上调6倍，其蛋白上调15倍 即蛋白比mRNA上调幅度大得多 这说明了什么？a受到转录后调控还是怎么的？ 小薇宝宝 这很正常，起码趋势是一致的，其中有一些实验误差，也有翻译水平的调控存在 伽利略 谢谢啊，如果不考虑实验误差问题，那蛋白比mRNA上调幅度大很多代表了什么，比如蛋白上调了100倍，mRNA只上调10倍。
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