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- CAS号:
551-11-1
- 规格:
1mg/1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg/200mg
| 规格: | 1mg | 产品价格: | ¥172.0 |
|---|---|---|---|
| 规格: | 1mLx10mM(inDMSO) | 产品价格: | ¥392.0 |
| 规格: | 5mg | 产品价格: | ¥354.0 |
| 规格: | 10mg | 产品价格: | ¥513.0 |
| 规格: | 25mg | 产品价格: | ¥1024.0 |
| 规格: | 50mg | 产品价格: | ¥1584.0 |
| 规格: | 100mg | 产品价格: | ¥2624.0 |
| 规格: | 200mg | 产品价格: | ¥3752.0 |
Product Introduction
Bioactivity
| 名称 | Dinoprost |
| 描述 | Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient. |
| 体外活性 | Dinoprost(前列腺素F2α;1 μM;24小时)在山羊黄体细胞中诱导ER应激、自噬和凋亡。Dinoprost(1 μM;24小时)显著提高了GRP78和UPR感应器的表达[3]。 |
| 存储条件 | Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : 100 mg/mL (282.1 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (11.28 mM), Sonication is recommended. DMSO : 100 mg/mL (282.1 mM), Sonication is recommended. |
| 关键字 | stress | Prostaglandin Receptor | Prostaglandin F2α | PGF2alpha | PGF2a | luteum | luteolytic | luminal | labour | Inhibitor | inhibit | Human Endogenous Metabolite | hormone | epithelium | EndogenousMetabolite | Endogenous Metabolite | Dinoprost | corpus | Autophagy | Apoptosis |
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| 相关库 | Bioactive Compound Library | Bioactive Compounds Library Max | Mouse Metabolite Compound Library | FDA-Approved Drug Library | Natural Product Library | GPCR Compound Library | Immunology/Inflammation Compound Library | Orally Active Compound Library | Drug Repurposing Compound Library | Natural Product Library for HTS | Human Metabolite Library | NMPA-Approved Drug Library |
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文献和实验Nature 解读:David R. Liu 等通过体内碱基编辑实现治疗小鼠Hutchinson-Gilford早衰综合征
注射 ABE 的小鼠(n=11)的中位生存期为 337 天(1.8 倍)。P14 生理盐水注射小鼠(n=12)的中位生存期为 215 天,而 P14 ABE 治疗小鼠(n=10)的中位生存期为 510 天(2.4 倍)。图片来源:NatureDavid R. Liu 教授的研究表明,ABE 作为一种在无需断裂双链 DNA 的情况下,可将基因中 A・T 碱基对转化为 G・C 碱基对的基因编辑手段,可直接纠正 HGPS 体内的致病突变,为 HGPS 提供了新的治疗方法。参考文献:1. Koblan
网络 附表11(1) 相关系数界值表 P(2): 0.50 0.20 0.10 0.05 0.02 0.01 0.005 0.002 0.001 P(1): 0.25 0.10 0.05 0.025 0.01 0.005 0.0025 0.001 0.0005 1 0.707 0.951 0.988 0.997 1.000 1.000
DNA Transposons for Modification of Human Primary T Lymphocytes
, 1998), viral infections (Science 285:546–551, 1999), and immunodeficiencies (Nat Rev Immunol 2:615–621, 2002). There are also significant implications for the study of T cell biology (J Exp Med 191:2031–2037, 2000). Currently, there are three types
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