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- 技术资料
- CAS号：
81098-60-4
- 规格：
1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg/200mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥295.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥239.0 |
| 规格： | 10mg | 产品价格： | ￥330.0 |
| 规格： | 25mg | 产品价格： | ￥447.0 |
| 规格： | 50mg | 产品价格： | ￥543.0 |
| 规格： | 100mg | 产品价格： | ￥984.0 |
| 规格： | 200mg | 产品价格： | ￥1576.0 |
| 规格： | 500mg | 产品价格： | ￥2664.0 |
Product Introduction
Bioactivity
| 名称 | Cisapride |
| 描述 | Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux. |
| 细胞实验 | Cells in the logarithmic growth phase are harvested and seeded in 96-well plates. The cell number is diluted to 5000/well in 200 microliters of RPMI1640 medium. In vitro experiments are carried out on the gastric cancer cell lines and GES cell line, using an MTT proliferation assay. MTT stains live cells, and the optical density absorbance at 490 nM wavelength correlates with the cell number. Cisapride is added to the cells at concentrations of 0, 12.5, 25, 50, 100 or 200 nM and equivalent volume of ethanol is added as control in order to eliminate the effects of solvent. Twenty microliters of MTT is added to each well of the cell culture 4 h before termination of the culture at 37?C. One hundred and fifty microliters of dimethyl sulfoxide is added to each well at the end of the culture and the plate is agitated for 10 minutes. The absorbency at 490 nm is read by a BIOHIT BP800 plate reader. Growth curve is drawn according to MTT colorimetry. The inhibition rate is calculated.(Only for Reference) |
| 体外活性 | Cisapride 独立于5-HT4受体激活，抑制血管Kv电流[2]。作为HERG通道阻滞剂，Cisapride 通过改变细胞周期分布并诱导凋亡，抑制胃癌细胞生长，具潜在胃癌治疗价值。Cisapride 能够以时间和剂量依赖的方式，通过HERG通道的特异性阻断抑制人类胃癌细胞系的生长和集落形成，而对GES细胞的影响较小[3]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.29 mM), Sonication is recommended. DMSO : 255 mg/mL (547.27 mM), Sonication is recommended. |
| 关键字 | Serotonin Receptor | R-51619 | R51619 | prokinetic agent | PotassiumChannel | Potassium Channel | patch-clamp | Inhibitor | inhibit | hERG | gastrointestinal | Cisapride | Cisaprid | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT4 agonist | 5-HT Receptor | 5HT Receptor | 5-HT |
| 相关产品 | Chenodeoxycholic acid | Cefaclor monohydrate | Cinchonidine | Alverine citrate | Dapoxetine hydrochloride | 2,2,2-Trichloroethanol | Uridine 5'-monophosphate disodium salt | Tetraethylammonium bromide | 1,8-Cineole | Ursodeoxycholic acid | Indapamide | Hydrochlorothiazide |
| 相关库 | Inhibitor Library | Anti-Cancer Approved Drug Library | Failed Clinical Trials Compound Library | FDA-Approved Drug Library | Ion Channel Targeted Library | Anti-Neurodegenerative Disease Compound Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Pain-Related Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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￥239 - 2664
