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- 文献和实验
- 技术资料
- CAS号：
638-94-8
- 规格：
1mLx10mM(inDMSO)/1g/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥95.0 |
|---|---|---|---|
| 规格： | 1g | 产品价格： | ￥174.0 |
| 规格： | 500mg | 产品价格： | ￥134.0 |
Product Introduction
Bioactivity
| 名称 | Desonide |
| 描述 | Desonide (Prednacinolone) is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release of arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Saline : < 10 mg/mL (24.01 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (24.01 mM), Solution. Ethanol : 28 mg/mL (67.23 mM), Sonication is recommended. DMSO : 250 mg/mL (600.23 mM), Sonication is recommended. |
| 关键字 | Inhibitor | inhibit | GlucocorticoidReceptor | Glucocorticoid Receptor | Desonide |
| 相关产品 | Formamide | Urea | Sodium Molybdate | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Citric Acid Triammonium | Stavudine | Tamoxifen |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Failed Clinical Trials Compound Library | Neuronal Signaling Compound Library | Anti-Aging Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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文献和实验Single tube confirmation PCR protocol
. For example, add 5 µl of the Zymo solution from isolate #1 to PCR tubes 1-5, 5 µl of the Zymo solution from isolate #2 to PCR tubes 6-10 and so on. - Make a PCR master mix by combining: 638 µl water, 110 µl 10 x Taq Buffer, 11 µl NTP's, and 11 µl Taq
Single tube confirmation PCR protocol
from isolate #2 to PCR tubes 6-10 and so on. - Make a PCR master mix by combining: 638 µl water, 110 µl 10 x Taq Buffer, 11 µl NTP's, and 11 µl Taq Polymerase. - Add 35 µl of the PCR mix to each of the 20 PCR tubes that already contain the 15 µl of primers
Single tube confirmation PCR protoco
of the Zymo solution from isolate #1 to PCR tubes 1-5, 5 µl of the Zymo solution from isolate #2 to PCR tubes 6-10 and so on. - Make a PCR master mix by combining: 638 µl water, 110 µl 10 x Taq Buffer, 11 µl NTP's, and 11 µl Taq Polymerase. - Add 35
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