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- CAS号：
13171-25-0
- 规格：
1mLx10mM(inDMSO)/25mg/50mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥150.0 |
|---|---|---|---|
| 规格： | 25mg | 产品价格： | ￥266.0 |
| 规格： | 50mg | 产品价格： | ￥362.0 |
Product Introduction
Bioactivity
| 名称 | Trimetazidine dihydrochloride |
| 描述 | Trimetazidine dihydrochloride (Vastarel F) can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in ischemic heart disease or angina. |
| 细胞实验 | The H9C2 cells are randomly assigned into three groups: Sham group, in which the cells are treated with 0μM TMZ for 48 h and then cultured under normal oxygenation conditions (5% CO2, and 95% air); H/R group, in which cells are treated with 0 μM TMZ for 48 h and then cultured under H/R conditions; and H/R+TMZ group, in which cells are treated with 10 μM TMZ for 48 h and then subjected to H/R treatment. (Only for Reference) |
| 体外活性 | TMZ给药可减小WT C57BL/6J心脏的心肌梗塞面积。AMPK与ERK信号传导途径共同介导了TMZ对缺血性损伤的心脏保护作用。Trimetazidine转变新陈代谢从脂肪酸氧化向葡萄糖氧化，并在缺氧条件下改善心肌细胞的收缩功能[2]。 |
| 体内活性 | TMZ给药可减小WT C57BL/6J心脏的心肌梗塞面积。AMPK与ERK信号传导途径共同介导了TMZ对缺血性损伤的心脏保护作用。Trimetazidine转变新陈代谢从脂肪酸氧化向葡萄糖氧化，并在缺氧条件下改善心肌细胞的收缩功能[2]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.9 mM), Sonication is recommended. DMSO : 65 mg/mL (191.59 mM), Sonication is recommended. |
| 关键字 | Trimetazidine dihydrochloride | Trimetazidine | mitochondrial long-chain 3-ketoacyl thiolase | Inhibitor | inhibit | FattyAcidSynthase | Fatty Acid Synthase | Autophagy |
| 相关产品 | Guanidine hydrochloride | Naringin | Enzalutamide | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Hemin | Hydroxychloroquine | Sildenafil citrate | Stavudine | Tamoxifen | Paeonol |
| 相关库 | Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compound Library | Bioactive Compounds Library Max | EMA Approved Drug Library | Anti-Aging Compound Library | Approved Drug Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library | NMPA-Approved Drug Library |
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盐酸曲美他嗪【13171-25-0】
￥150 - 362
