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- 2026年07月07日
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- 详细信息
- 文献和实验
- 技术资料
- CAS号：
94-20-2
- 规格：
1mLx10mM(inDMSO)/1g/5g/10g/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥233.0 |
|---|---|---|---|
| 规格： | 1g | 产品价格： | ￥295.0 |
| 规格： | 5g | 产品价格： | ￥669.0 |
| 规格： | 10g | 产品价格： | ￥984.0 |
| 规格： | 100mg | 产品价格： | ￥111.0 |
| 规格： | 500mg | 产品价格： | ￥213.0 |
Product Introduction
Bioactivity
| 名称 | Chlorpropamide |
| 描述 | Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. |
| 激酶实验 | Androgen Receptor Assay: Aliquots of 100 μl cytosol are incubated at 0-4°C for 18 h with 100 μl of the indicated saturating concentration of [3H]T in the presence or absence of increasing concentrations of nonlabeled T, DHT, flutamide (FLU) or flutamide-OH (FLU-OH). At the end of the incubation, free and bound T are separated by the addition of 200 μl dextran-coated charcoal (1 % charcoal, 0.1% dextran T-70, 0.1% gelatin, 1.5 mM EDTA and 50 mM Tris (pH 7.4)) for 15 min before centrifugation at 2300 × g for another 15 min at 0-4°C. Aliquots (350 μl) of the supernatant are transferred to scintillation vials with 10 ml of an aqueous counting solution before counting in a Beckman LS 330 counter. |
| 体内活性 | 0.2 mM的Chlorpropamide提高了家鼠体内分离出的肝细胞中fructose-2,6-bisphosphate (F-2,6-P2)的浓度。Chlorpropamide通过环AMP-非依赖性机制发挥作用。Chlorpropamide会增强胰岛素对胰高血糖素受激的糖异生的抑制作用。在胰岛素缺乏（30％）或者存在（31％）的情况下,Chlorpropamide都能显著增加葡萄糖代谢和总脂质。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.23 mM), Sonication is recommended. Ethanol : 51 mg/mL (184.29 mM), Sonication is recommended. DMSO : 55 mg/mL (198.74 mM), Sonication is recommended. |
| 关键字 | Sodium potassium pump | Na+/K+ ATPase | Inhibitor | inhibit | Chlorpropamide | ABCC8 |
| 相关产品 | Acridone | Sodium orthovanadate | 2,3-Butanedione 2-Monoxime | Oleic acid | Vigabatrin | Revaprazan hydrochloride | Probucol | Permethrin | Vismodegib | trans-Aconitic acid | Sodium oleate | Phlorizin |
| 相关库 | Anti-Cancer Approved Drug Library | Drug-induced Liver Injury (DILI) Compound Library | FDA-Approved & Pharmacopeia Drug Library | NO PAINS Compound Library | FDA-Approved Drug Library | Membrane Protein-targeted Compound Library | Orally Active Compound Library | Drug Repurposing Compound Library | Anti-Metabolism Disease Compound Library | Human Metabolite Library | Anti-Cancer Drug Library | NMPA-Approved Drug Library |
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文献和实验,Taq PCR MasterMix 扩增产物可用于 T/A 克隆。本产品加入特殊稳定剂，37 ℃ 温度下 48 h仍然保持 95% 以上的扩增效率．储存条件： -20 ℃ 一年有效，多次冻融不会影响活性，经常使用可放置于 4 ℃。 本品为适应大部分 PCR 反应需要，Taq 酶量是按照 PCR 反应酶量上限所加，如出现 PCR 反应非特异性扩增明显或者背景过高，可将 Taq PCR MasterMix 反应液适当稀释后使用，可改善 PCR 扩增效果。 PCR 反应液： 组成成分 50
onto the top of the mineral oil overlay. Set sample in ice bucket until all samples have been prepared. Microfuge briefly to move the master mix through the mineral oil overlay. Rapidly heat the samples to 94°C and cycle 30 times through a program appropriate
Single tube confirmation PCR protocol
are for isolate #1, 6-10 are for isolate #2, ..., and tubes 16-20 are for the wild-type control. Each of the 20 tubes should contain 10 µl of the primer mix (5 µl of each primer). - Add the 5 µl of the Zymo treated cells to each of the 20 PCR reactions
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