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- CAS号：
38396-39-3
- 规格：
1mLx10mM(inDMSO)/50mg/100mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥437.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥290.0 |
| 规格： | 100mg | 产品价格： | ￥397.0 |
Product Introduction
Bioactivity
| 名称 | Bupivacaine |
| 描述 | Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain. |
| 体外活性 | Bupivacaine inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically involved in central sensitization[1]. Bupivacaine influences the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward somewhat more negative membrane potentials. In their inactivated state, SCN5A channels are slightly sensitive toward Bupivacaine IC50=2.18±0.16 μM[2]. Bupivacaine reversibly inhibits the SK2 channel in a dose-dependent manner with the IC 50 of 16.5 µM[3]. |
| 存储条件 | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Saline : 2.78 mg/mL (9.64 mM), Solution. DMSO : 27.78 mg/mL (96.31 mM), Sonication is recommended. |
| 关键字 | SodiumChannel | Sodium Channel | NMDA receptor | Bupivacaine |
| 相关产品 | L-Glutamic acid | Valproic Acid | Urethane | Magnesium Chloride Hexahydrate | 2,4,6-Tri-tert-butylphenol | 1,8-Cineole | L-Ascorbic acid sodium salt | L-Ascorbic acid | Indole-2-carboxylic acid | Quadrol | Magnesium sulfate | Phenytoin sodium |
| 相关库 | Neuroprotective Compound Library | Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | ReFRAME Related Library | EMA Approved Drug Library | FDA-Approved Drug Library | Ion Channel Targeted Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Pain-Related Compound Library |
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62 99 2.6 0.13 0.8 布比卡因 bupivacaine - 2 95 7.1 0.9 2.4 咖啡因 caffeine 100
布美他尼bumetanide 81 62 99 2.6 0.13 0.8 布比卡因bupivacaine - 2 95 7.1 0.9 2.4 咖啡因caffeine 100 1.1 36
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布比卡因【38396-39-3】
￥290 - 437
