人B-淋巴细胞趋化因子1(BLC1)微量上样酶联免疫吸附检测
试剂盒【Human BLC1(B-Lymphocyte Chemoattractant 1) Microsample ELISA Kit】- ￥1680 - 2400
- ELK Biotechnology
- 15.63-1000 pg/mL
- 6.3 pg/mL
- 武汉
- ELK1106MS
- 2026年05月21日
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- 文献和实验
- 技术资料
- 供应商：
武汉研升生物科有限公司
- 检测范围：
15.63-1000 pg/mL
- 检测方法：
Sandwich
- 适应物种：
Human
- 样本：
serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids
- 灵敏度：
6.3 pg/mL
- 规格：
48T/96T
| 规格： | 48T | 产品价格： | ￥1680.0 |
|---|---|---|---|
| 规格： | 96T | 产品价格： | ￥2400.0 |
| 中文名称 | 人B-淋巴细胞趋化因子1(BLC1)微量上样酶联免疫吸附检测试剂盒 |
| 英文名称 | Human BLC1(B-Lymphocyte Chemoattractant 1) Microsample ELISA Kit |
| 别名 | CXCL13; SCYB13; BLC; BCA1; BLR1L; ANGIE; ANGIE2; Chemokine(C-X-C-Motif)ligand 13; Small Inducible Cytokine B Subfamily(Cys-X-Cys Motif)Member 13 |
| 货号 | ELK1106MS |
| 反应种属 | Human |
| 检测类型 | Sandwich |
| 灵敏度 | 6.3 pg/mL |
| 标准品 | 1000 pg/mL |
| 检测范围 | 15.63-1000 pg/mL |
| 样本类型 | serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
| 反应时间 | 3.5h |
| 检测原理 | The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BLC1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human BLC1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human BLC1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BLC1 in the samples is then determined by comparing the OD of the samples to the standard curve. |
| 研究领域 | Cytokine;Tumor immunity;Infection immunity;Immune molecule;Hematology; |
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文献和实验细胞识别。 激活的B细胞能够从T细胞区回到淋巴滤泡，是因为发生了B-FDC间的相互作用。一方面，激活的B细胞可产生TNF家族成员淋巴毒素(LT)，促使FDC发育；另一方面，FDC分泌一种称为B细胞趋化因子(B-lympho cytechemoklne，BLC)(CXCLl3)的趋化蛋白，而B细胞可组成性地表达BLC的受体CXCR5。这是B细胞能够进入并停留在B细胞区的原因。 这说明，B细胞在早期时相中的活动和迁徙直接由T细胞区和B细胞区中占主导地位的趋化因子，以及B细胞趋化因子
9 T细胞, B细胞, 树突状细胞, 活化的自然杀伤细胞, 巨噬细胞祖细胞 CCL22 SCYA22 MDC, ABCD-1 (mouse), DC/B-CK (mouse) T细胞, 嗜酸性细胞 CCL23 SCYA23 MIP-3, MPIF-1, CKbeta
A chemokine-driven positive feedback loop organizes lymphoid follicles
such cells. Using gene-targeted mice, we establish that B-lymphocyte chemoattractant (BLC/BCA1) 2 , 3 and its receptor, CXCR5, are needed for B-cell homing to follicles in lymph nodes as well as in spleen. We also find that BLC is required
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