人乳头瘤病毒31型E6/E7（HPV31）RNA标准品Hum

HPV 并不是宫颈癌唯一的「元凶」？这种微生物化身「帮凶」，共同促进癌症发生

-3a、MG-132 和 Lactacystin 处理 hCEcto E6E7 干细胞。结果显示，所有处理条件都降低了沙眼衣原体的感染性。以上结果表明，蛋白酶体降解是一种重要机制，可明显调节 E2F 介导的 MMR 基因转录并减少共感染中的 p53、E2F 和 MMR 蛋白。 图片来源：Nature Communications 研究意义 超过 80% 的女性在其一生中会感染 HPV，但只有不到 2% 的女性会患上宫颈癌。而宫颈癌患者常常同时感染人乳头瘤病毒（HPV）和沙眼衣原体，因此科学

Human Papillomavirus Type 31 Life Cycle Methods for Study Using Tissue Culture Models

cycle. Normal human keratinocytes (NHKs) harvested from neonatal foreskins were transfected with HPV type 31 genomes in order to generate stable cell lines containing episomal copies of HPV genomes. HPV-positive keratinocyte cultures were maintained in E

Selective Silencing of Viral Gene E6 and E7 Expression in HPV-Positive Human Cervical Carcinoma Cells Using Small Interfering RNAs

cancer cells as a model, we demonstrate RNAi for viral oncogenes Cervical cancer is the second most common cancer in women worldwide and is caused by human papillomavirus (HPV). Silencing of HPV E6 and E7 gene expression was achieved using siRNAs