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文献和实验Overexpression Models: Lentiviral Modeling of Brain Cancer
. Uhrbom, L., Hesselager, G., Nister, M., and Westermark, B. 1998. Induction of brain tumors in mice using a recombinant platelet‐derived growth factor B‐chain retrovirus. Cancer Res. 58:5275‐5279
EGFR and Tumor Suppressor Function in Brain Cancer Development
Genetically engineered mouse models (GEMM) of glioblastoma multiforme (GBM) provide a system in which de novo tumors arise and develop within the context of a proper tumor microenvironment. These models are considered superior to orthotopic
Alterations in the copy number of the cancer genome are frequently observed in brain tumors especially gliomas. Some pertinent examples include amplification of the EGFR locus in chromosome 7p and loss of the PTEN locus in 10q in glioblastoma
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