- ￥2980 - 9980
- Sino Biological
- 北京
- 18845-H86H-SA
- 2026年01月22日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant Human GUCY2C/Guanylyl cyclase C Protein (Site-Specific APC Conjugation, His Tag)
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
25.00 Tests/100.00 Tests
| 规格： | 25.00 Tests | 产品价格： | ￥2980.0 |
|---|---|---|---|
| 规格： | 100.00 Tests | 产品价格： | ￥9980.0 |
蛋白名称：Human Human GUCY2C/Guanylyl cyclase C Protein (Site-Specific APC Conjugation, His Tag)
蛋白构建：A DNA sequence encoding the human GUCY2C (P25092-1) (Met 1-Gln 430) was expressed with a C-terminal polyhistidine tag. The protein is site-specifically conjugated with APC (Excitation Max.= 651 nm, Emission Max.= 662 nm).
表达宿主：HEK293 Cells
蛋白活性：1.Flow cytometric analysis of anti-GUCY2C CAR expression. 5e5 of anti-GUCY2C CAR-293 cells were stained with 100 μL of 1:50 (2 μL stock solution in 100 μL FACS buffer) of APC-conjugated human GUCY2C/Guanylyl cyclase C Protein (Site-Specific APC Conjugation, His Tag, Cat. No. 18845-H86H-SA) and negative control protein. Non-transduced 293 cells were used as a control (left). APC signal was used to evaluate the binding activity (QC tested). 2.Binding activity of APC-conjugated GUCY2C protein to PBMC cells. PBMC cells were stained with FITC conjugated anti-CD3 antibody and APC-conjugated human GUCY2C/Guanylyl cyclase C Protein (Site-Specific APC Conjugation, His Tag, Cat. No. 18845-H86H-SA) and detected by flow cytometry. FITC signal was used to evaluate the content of CD3+ T cells in PBMCs. APC signal was used to evaluate the non-specific binding activity to PBMCs (QC tested).
蛋白内毒素：Please contact us for more information.
预测N端：Ser 24
蛋白分子量：The protein has a predicted molecular mass of 49.8 kDa.
蛋白NP号：P25092-1
蛋白氨基酸序列：Met1-Gln430
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文献和实验-operated clannel）开放，从而产生效应。例如β受体激动使钙离子通道开放，Ca 2+ 进入细胞而产生各种生理效应。 有些受体含有离子通道，如上述N胆碱受体，与配体结合就能直接使通道开放。故称这种受体为门控通道型受体。 （二）受体与酶的偶联 传出神经系统的G蛋白偶联受体是通过腺苷酸环化酶（adenyl cyclase,AC）或磷脂酶C（phospholipase C, PLC）而产生效应的（图5-9）。 图5-9 受体-腺苷酸环化酶偶联
receptor family）以及一些神经递质受体都属于G蛋白偶联的7次跨膜受体的超家族。例如IL-8RA胞膜外N端Asp11、Llu275、Arg280以及可形成二硫键的Cys30和Cys277在与配体结合中起重要作用；紧接第三个空膜区第二个胞浆环中DRY序列对于与G蛋白的结合是必要的。 （1）Gs：细胞表面受体与Gs（stimulating adenylate cyclase g protein,Gs）偶联激活腺苷酸环化酶，产生cAMP第二信使，继而激活cAMP依赖的蛋白激酶。
control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes." Circ Res 107(10): 1232-1240. 2. Guo, D., J. J. Zhang, et al. (2009). "Stimulation of guanylyl cyclase-D
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