HLA Class I Bw4 Antibody, anti

Identification and enumeration of HLA class I Bw4+ cells by flow cytometryClone REA274 recognizes HLA Bw4, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. Analysis of HIV-infected patients found the combination of the NK cell receptor KIR3DS1/L1 and a presumptive HLA Bw4 ligand to be correlated with slower progression to AIDS. | Additional information: Clone REA274 displays negligible binding to Fc receptors. |