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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
polypeptide, sealed storage, away from moisture
- 英文名：
Human pancreatic polypeptide
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
75976-10-2
- 规格：
500 μg/1 mg
| 规格： | 500 μg | 产品价格： | ￥2400.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥4100.0 |
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Pancreatic Polypeptide, human
CAS No. : 75976-10-2
MCE 国际站：Pancreatic Polypeptide, human
产品活性：Pancreatic Polypeptide, human 是一种 C-末端酰胺化的含 36 个氨基酸的多肽，用作神经肽 Y (NPY) Y4/Y5 受体激动剂。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Neuropeptide Y Receptor
In Vitro: Human pancreatic polypeptide (hPP) is one such peptide, being released postprandially from F cells of the pancreatic islets depending on caloric load, food consumption and circadian rhythm. It is a C-terminally amidated 36 amino acid peptide with a characteristic hairpin-like pancreatic polypeptide (PP)-fold and acts at the Y4 receptor to induce satiety and delay gastric emptying and motility. Addition of the human pancreatic polypeptide (hPP) (10 nM-1 μM) results in a significant, dose-dependent reduction in both basal and stimulated release. Human pancreatic polypeptide (hPP) can also inhibit basal and stimulated NPY release with a pharmacological profile suggesting a role for Y4 presynaptic receptors.
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文献和实验Culture of Human Pancreatic Islet Cells
The pancreatic islet is a microorgan composed of four types of hormone-producing cells. In the human pancreas, the islets comprise about l–2%; of the pancreatic mass, and the islet number is approx 1−2 � 106 . The majority of cells
Ribozymes as a Novel Approach for the Treatment of Human Pancreatic carcinoma
), and the human immunodeficiency virus type 1 (10 ,14 ,15 ). Our Studies have previously demonstrated that anti-oncogene ribozymes effectively suppress the expression of targeted genes and result in the reversal of the malignant phenotype in human cancer cells
. N 6-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis. Nature Communications, 2022, 13.1: 4148. 【5】Zhu S, Russ H A, Wang X, et al. Human pancreatic beta-like cells
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