Balanophonin蛇菰宁,80286-36-8

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Balanophonin

CAS No. : 80286-36-8

MCE 国际站：Balanophonin

产品活性：Balanophonin 是一种抗炎和抗癌剂。Balanophonin 通过抑制激活的小胶质细胞诱导的凋亡 (apoptosis) 来抑制小胶质细胞激活和神经退行性变。

研究领域：Apoptosis  |  Immunology/Inflammation  |  MAPK/ERK Pathway

作用靶点：Apoptosis  |  COX  |  TNF Receptor  |  p38 MAPK

In Vitro: Balanophonin (1-10 μM; 24 h) reduces Lipopolysaccharides (LPS; HY-D1056)-mediated TLR4 activation and NO production in BV2 cells.
Balanophonin (1-10 μM; 6 h) reduces iNOS and COX2 protein expression and TNF-α and IL-1β production in LPS-induced microglial cells.
Balanophonin (1-10 μM; 30 min) effectively inhibits MAPK activation.
Balanophonin (1-10 μM; 24 h) inhibits neuronal cell death resulting from LPS-activated microglia by regulating cleaved caspase-3 and poly ADP ribose polymerase (PARP) cleavage in N2a cells.

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