P-糖蛋白(抗体)

P-糖蛋白(抗体)产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

P-糖蛋白(抗体)产品介绍

信号传导（Signaling Intermediates）
Pgp是多药耐药(MDR)基因产物，作为“药泵”功能引起癌细胞产生耐药，主要用于各种恶性肿瘤(如肾细胞癌、肝癌、胃肠道癌、乳腺癌等)的研究。
PgP容易产生耐药的抗药药物主要为长春花碱类和阿霉素等，因此对肿瘤病人选择化疗方案和预后的判断具有重要的临床意义。

P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.
mol wt:141kDa
Other Aliases:
P-Glycoprotein; Multi Drug Resistance Associated Protein, ABCB1; ATP-binding cassette sub-family B (MDR/TAP), member 1; ABC20; CD243; CD243 antigen; CLCS; Multidrug resistance protein 1; P glycoprotein 1; p-GP; gp170; P gp; PGY1

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zk-0297zks Donkey anti-human IgG whole serum驴抗人IgG抗血清
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zk-0326G Goat Anti-Bovine IgG羊抗牛IgG
zk-0326M Mouse Anti-Bov IgG小鼠抗牛IgG
P-糖蛋白(抗体)