- $67
- Alomone
- ZK-0039497
- 以色列
- 2025年11月20日
- 见官方网站
- Synthetic
- 见官方网站
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- 详细信息
- 技术资料
- 供应商：
上海再康生物科技有限公司
- 库存：
大量
- 靶点：
见官方网站
- 级别：
高
- 目录编号：
S-210
- 克隆性：
多克隆
- 抗原来源：
Synthetic
- 保质期：
6个月
- 抗体英文名：
SNAP 37889
- 抗体名：
SNAP 37889
- 标记物：
见官方网站
- 宿主：
Synthetic
- 适应物种：
见官方网站
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 保存条件：
-20°C
- 规格：
10 mg, 25 mg, 50 mg, 100 mg
SNAP 37889
HT-2157A Selective Antagonist of Galanin 3 Receptor
Cat #: S-210
Sizes: 10 mg, 25 mg, 50 mg, 100 mg
Source: Synthetic
MW: 366.34 Da.
Target: Galanin 3 receptor
CLICK HERE TO RECEIVE A 10 mg FREE TRIAL SAMPLE!
SNAP 37889 is a potent and selective Galanin 3 receptor (GalR3) antagonist. The compound exists as E– and Z-isomers that interconvert quickly in solution at room temperature1,2.
Studies conducted in animals show that acute administration of SNAP 37889 enhances rat social interaction, reduces guinea pig vocalizations after maternal separation, and attenuates stress-induced hyperthermia in mice1.
Galanin is a widely distributed neuropeptide that regulates various endocrine, pain and cognitive functions, including learning and memory in the central nervous system (CNS). It activates one of three receptors belonging to the GPCR superfamily: GalR1, GalR2 and GalR3. GAL3 receptors are involved in anxiety, depression, and drug-seeking behavior1,2.
References
- Swanson, C.J. et al. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 17489.
- Scheller, K.J. et al. (2014) MethodsX 1, 212.
- Webling, K. et al. (2016) Neuropeptides 60, 75.
- Our Bioassay
- Specifications
- Related Products
Alomone Labs SNAP 37889 inhibits GalR2 receptor-mediated Ca2+mobilization in CHO-K1-Gα16-mt-Aequorin cells.
Dose response of normalized SNAP 37889 (#S-210) inhibition of the galanin-evoked, GalR2 receptor-mediated Ca2+ mobilization, measured as aequorin-derived fluorescence following galanin application (IC50 = 7.57 µM).
Purity>98%.
Effective concentration10 nM – 10 µM.
Chemical name1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one.
Molecular formulaC21H13F3N2O.
CAS number303149-14-6.
ActivitySNAP 37889 is a potent GalR3 galanin receptor antagonist, highly selective for GalR3 (Ki = 17.44 nM) over GalR1 and GalR2 (Ki > 10 µM), showing anxiolytic and antidepressant-like effects in rodent models in vivo1-2.
Storage before reconstitutionProduct before reconstitution should be stored at -20°C.
ReconstitutionSoluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitutionUp to three months at -20°C.
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