Antisense Blockade of Expression: SNAP-25 In Vitro and In Vivo

With the advent of modern molecular genetics and molecular biology, we will face more and more situations where novel gene products with unknown functions are identified. Genetic linkage analysis will allow the association of novel or known genes to Important diseases (1 ). Similarly, sensitlve differential cloning procedures will identify rare genes expressed in specific physiological or pathological situations (1 , 3 ). In both cases, establishing the precise function of the identified gene is an essential step for the understanding of the cellular mechanisms that either lead to the disease or are pivotal in important physiological processes.